Evidence map›Paper›PMID 41326173›Full record

ArticleLife science alliance2026

TRPM7 and magnesium orchestrate human CD4 T-cell activation and differentiation.

Anna Madlmayr, Kilian Hoelting, Birgit Karner-Hoeger, Dorothea Lewitz, Marius Weng, Severin Hacker, Julia Eder, Katharina Horner, Christine Schedlberger, Tanja Haider and 8 more

Abstract read
In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Anna MadlmayrInstitute of Pharmacology, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria.ORCID 0000-0002-4518-147X
Kilian HoeltingWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Birgit Karner-HoegerInstitute of Pharmacology, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria.ORCID 0000-0001-7491-9405
Dorothea LewitzWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Marius WengInstitute of Pharmacology, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria.
Severin HackerInstitute of Pharmacology, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria.
Julia EderInstitute of Pharmacology, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria.
Katharina HornerInstitute of Pharmacology, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria.
Christine SchedlbergerInstitute of Pharmacology, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria.
Tanja HaiderInstitute of Pharmacology, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria.
Max LechnerWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Michelle DugganInstitute of Pharmacology, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria.
Rylee RossLaboratory of Marine Biological Chemistry, Hawai'i Pacific University, Honolulu, HI, USA.
F David HorgenLaboratory of Marine Biological Chemistry, Hawai'i Pacific University, Honolulu, HI, USA.
Markus SperandioInstitute of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians-Universität München, München, Germany.ORCID 0000-0002-7689-3613
Alexander DietrichWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0002-1168-8707
Thomas GudermannWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0002-0323-7965
Susanna ZierlerInstitute of Pharmacology, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria susanna.zierler@jku.at.ORCID 0000-0002-4684-0385

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
NIGMS NIH HHS P20 GM103466
6 · The paper itself

Abstract

T-lymphocyte activation is a crucial process in the regulation of innate and adaptive immune responses. The ion channel-kinase TRPM7,

Indexed as

CD4-Positive T-LymphocytesCell DifferentiationLymphocyte ActivationMagnesiumProtein Serine-Threonine KinasesTRPM Cation ChannelsHumansInterleukin-2Jurkat CellsSignal TransductionTh17 CellsT-Lymphocytes, RegulatoryInterleukin-2MagnesiumProtein Serine-Threonine KinasesTRPM7 protein, humanTRPM Cation Channels

Identifiers

PMID41326173
PMCPMC12670122

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.