Evidence map›Paper›PMID 41326205›Full record

ArticleeNeuro2025

Altered PI3K/mTOR Signaling within the Forebrain Leads to Respiratory Deficits in a Mouse Model of Epilepsy.

Patrick Woller, Vamshidhar Singidi, McKenzie Rice, Durgesh Tiwari, Christina Gross, Steven A Crone

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Patrick WollerNeuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267.ORCID https://orcid.org/0000-0002-5952-8729
Vamshidhar SingidiDepartment of Medical Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267.
McKenzie RiceDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Durgesh TiwariNeuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267.
Christina GrossNeuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267.ORCID https://orcid.org/0000-0001-6057-2527
Steven A CroneDivision of Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229 steven.crone@cchmc.org.ORCID https://orcid.org/0000-0001-9644-2767

Funding

PREDOCTORAL TRAINING PROGRAM IN THE NEUROSCIENCEST32NS007453 · NINDS · UNIVERSITY OF CINCINNATI · PI HERMAN, JAMES P · 1997 to 2025
$4.0M
Spinal circuitry for ventilatory control and compensationR01NS112255 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI CRONE, STEVEN ALLEN · 2019 to 2023
$1.7M
Assessing the contribution of altered PI3K signaling to breathing abnormalities and sudden death in epilepsyR21NS121644 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI CRONE, STEVEN ALLEN, GROSS, CHRISTINA · 2022 to 2023
$437k
NINDS NIH HHS R01 NS112255NINDS NIH HHS R21 NS121644NINDS NIH HHS T32 NS007453
6 · The paper itself

Abstract

People with epilepsy may experience sudden death due to respiratory failure through mechanisms that are currently not well understood. Epilepsy causing mutations are thought to elicit seizures due to altered function of forebrain circuits, yet breathing is controlled largely by the brainstem. To investigate how altered forebrain activity could impact breathing, we examined respiratory and seizure phenotypes in a mouse epilepsy model with a forebrain-specific deletion of the phosphatase and tensin homolog (

Indexed as

EpilepsyPhosphatidylinositol 3-KinasesProsencephalonSignal TransductionTOR Serine-Threonine KinasesAnimalsDisease Models, AnimalElectroencephalographyFemaleMaleMiceMice, Inbred C57BLMice, KnockoutPTEN PhosphohydrolaseSeizuresmTOR protein, mousePhosphatidylinositol 3-KinasesPTEN PhosphohydrolasePten protein, mouseTOR Serine-Threonine Kinasesbreathingdiaphragm electromyographyepilepsyforebrain control of breathingmTOR pathwaysudden unexpected death in epilepsy

Identifiers

PMID41326205
PMCPMC12711331

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.