ArticleCell death discovery2025
USP25 attenuates the immunosuppressive tumor microenvironment via the deubiquitination of TAB2 in head and neck squamous cell carcinoma.
Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
Funding
Abstract
The role of deubiquitinating enzymes in the tumor immune microenvironment (TIME) remains understudied. Here, we sought to identify the mechanisms of USP25 modulation in the TIME of head and neck squamous cell carcinoma (HNSCC). Bioinformatics analysis was performed to screen differentially expressed novel deubiquitinases (DUBs) in HNSCC. The importance of USP25 in clinical practice was assessed in the TCGA dataset and tissue microarrays. Single-cell RNA-sequencing was applied to profile the TIME. The function of USP25 was determined through loss-of-function assays. Reduced expression of USP25 was associated with the malignant progression of HNSCC and further indicated poor prognosis. USP25 protein levels were positively correlated with CD8
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