SynthesisNeurosurgical review2025
Prognostic nutritional indices and functional outcome in patients with subarachnoid hemorrhage: a meta-analysis.
Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalnutrition is a prevalent but often overlooked factor influencing neurological recovery in patients with subarachnoid hemorrhage (SAH). Nutritional indices such as the Prognostic Nutritional Index (PNI), Controlling Nutritional Status (CONUT) score, and Geriatric Nutritional Risk Index (GNRI) have been proposed as prognostic markers, yet their association with functional outcomes in aSAH remains unclear.
methodsWe conducted a meta-analysis of observational cohort studies evaluating the relationship between malnutrition-defined by low PNI, high CONUT, or low GNRI at admission-and poor functional outcome, defined as modified Rankin Scale ≥ 3 or Glasgow Outcome Scale ≤ 3. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using a random-effects model by incorporating the influence of heterogeneity.
resultsSix studies comprising seven datasets and 1,048 patients were included. Malnutrition was significantly associated with increased odds of poor functional outcome (OR: 1.64; 95% CI: 1.24-2.16; I² = 59%). Subgroup analyses showed consistent associations across PNI (OR: 1.38), CONUT (OR: 2.01), and GNRI (OR: 1.61; p for subgroup difference = 0.24). Stronger associations were observed in studies with ≥ 40% men (OR: 3.07) compared to those with < 40% men (OR: 1.43; p for subgroup difference = 0.04), and in studies with 3-month follow-up (OR: 3.55) compared to those assessing outcomes at discharge (OR: 1.31) or 6 months (OR: 1.32; p for subgroup difference = 0.003).
conclusionsAdmission malnutrition, as identified by nutritional indices, was associated with poor functional outcomes in patients with aneurysmal SAH.
Indexed as
Identifiers
41326780What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.