Evidence map›Paper›PMID 41326784›Full record

ArticleBehavior research methods2025

Triggering just-in-time adaptive interventions based on real-time detection of daily-life stress: Methodological development and longitudinal multicenter evaluation.

S A Bögemann, F Krause, A van Kraaij, M A Marciniak, J M van Leeuwen, J Weermeijer, J Mituniewicz, L M C Puhlmann, M Zerban, Z C Reppmann and 9 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Behavior research methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

S A BögemannDonders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. sophie.bogemann@donders.ru.nl.ORCID http://orcid.org/0000-0001-9382-0769
F KrauseDonders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
A van KraaijOnePlanet Research Center, OnePlanet Research Center, Wageningen, The Netherlands.
M A MarciniakDivision of Experimental Psychopathology and Psychotherapy, Department of Psychology, University of Zurich, Zurich, Switzerland.
J M van LeeuwenDonders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
J WeermeijerCenter for Contextual Psychiatry, Department of Neurosciences, KU Leuven, Leuven, Belgium.
J MituniewiczFaculty of Psychology, University of Warsaw, Warsaw, Poland.
L M C PuhlmannLeibniz Institute for Resilience Research, Mainz, Germany.
M ZerbanNeuroimaging Center, Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center, Mainz, Germany.
Z C ReppmannDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Corporate Member of FU Berlin and Humboldt Universität Zu Berlin, Berlin, Germany.
D KobylińskaFaculty of Psychology, University of Warsaw, Warsaw, Poland.
K S L YuenLeibniz Institute for Resilience Research, Mainz, Germany.
B KleimDivision of Experimental Psychopathology and Psychotherapy, Department of Psychology, University of Zurich, Zurich, Switzerland.
H WalterDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Corporate Member of FU Berlin and Humboldt Universität Zu Berlin, Berlin, Germany.
I Myin-GermeysCenter for Contextual Psychiatry, Department of Neurosciences, KU Leuven, Leuven, Belgium.
R KalischLeibniz Institute for Resilience Research, Mainz, Germany.
I M VeerDepartment of Developmental Psychology, University of Amsterdam, Amsterdam, The Netherlands.
K RoelofsBehavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
E J HermansDonders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress-related disorders present a significant global burden, highlighting the need for effective, preventive measures. Mobile just-in-time adaptive interventions (JITAI) can be applied in real time and context-specifically, precisely when individuals need them most. Yet, they are rarely applied in stress research. This study introduces a novel approach by performing real-time analysis of both psychological and physiological data to trigger interventions during moments of high stress. We evaluated the feasibility of this JITAI algorithm, which integrates ecological momentary assessments (EMA) and ecological physiological assessments (EPA) to generate a stress score that triggers interventions in real time by relating the score to a personalized stress threshold. The feasibility of the technical implementation, participant adherence, and user experience were assessed within a multicenter study with 215 participants conducted across five research sites. The JITAI algorithm successfully processed EMA and EPA data to trigger real-time interventions. A total of 68% (standard deviation [SD] = 29%) of EMA beeps contained extracted EPA features, demonstrating technical feasibility. The algorithm triggered 1.61 (SD = 1.26) interventions per day, with 43% (SD = 27%) of EMA beeps per week leading to triggered interventions. Compliance rates of 43% (SD = 22%) for EMA and 43% (SD = 30%) for the JITAI were achieved, with feedback indicating areas for improvement, particularly for daily-life integration. Our findings provide preliminary support for the feasibility of the developed JITAI algorithm, demonstrating effective data processing and intervention triggering in real time, while also highlighting areas for improvement. Future research should focus on minimizing participant burden, including the intensity of EMA protocols, to improve participant adherence and acceptability while maintaining the benefits of real-time intervention delivery.

Indexed as

Ecological Momentary AssessmentStress, PsychologicalAdultAlgorithmsFeasibility StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedYoung AdultEcological momentary assessmentEcological momentary interventionEcological physiological assessmentJust-in-time adaptive interventionMental healthResilienceStress

Identifiers

PMID41326784

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.