SynthesisBMC public health2025
Dietary amino acid intake and the risk of hypertension: a systematic review and meta-analysis.
Synthesis in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHypertension (HTN) is a major global health burden. While dietary protein is a known modifiable risk factor, the role of specific amino acids remains controversial. This systematic review and meta-analysis investigates the association between dietary amino acid intake and the risk of hypertension.
methodsThree electronic databases (PubMed, Scopus, Web of Science) were systematically searched from inception until September 30, 2025 for observational studies examining dietary amino acid intake and hypertension. Data extraction and quality assessment were performed. Where applicable, meta-analyses were conducted using a fixed-effect model to pool effect estimates.
resultsThe sixteen included studies, with a total of 57,913 participants, comprised eight prospective cohorts, five cross-sectional studies, and three that utilized other designs. The meta-analysis of adjusted odds ratios (ORs) showed that higher intake of branched-chain, aromatic, and alcoholic amino acids was associated with a significantly increased risk of hypertension, with pooled ORs of 1.37 (95% CI: 1.14-1.66), 1.50 (95% CI: 1.22-1.85), and 1.66 (95% CI: 1.31-2.11) for the second, third, and fourth quartiles, respectively. Prospectively, higher intake of branched-chain amino acids significantly increased the hazard of hypertension. Conversely, glycine intake was consistently associated with a protective effect (pooled OR = 0.75; 95% CI: 0.64-0.89).
conclusionSpecific dietary amino acids have distinct associations with HTN risk. Branched-chain and aromatic amino acids are associated with increased risk, while glycine demonstrates a protective effect. These findings highlight the potential for specific dietary recommendations but are limited by methodological heterogeneity across studies. Future research with standardized methodologies is needed to confirm these associations and inform clinical and public health guidance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.