Evidence map›Paper›PMID 41327116›Full record

ArticleBMC palliative care2025

Assessing the health-related quality of life in informal caregivers of Alzheimer's Disease: evidence from Malaysia.

Lyn Xuan Tay, Siew Chin Ong, Hui Ming Ong, Ewe Eow Teh, Alan Swee Hock Ch'ng, Ing Khieng Tiong, Rizah Mazzuin Razali, Thaigarajan Parumasivam

Abstract read
In one paragraph

Article in BMC palliative care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lyn Xuan TayDiscipline of Social and Administrative Pharmacy, Universiti Sains Malaysia, Georgetown, Pulau Pinang, 11800, Malaysia.
Siew Chin OngDiscipline of Social and Administrative Pharmacy, Universiti Sains Malaysia, Georgetown, Pulau Pinang, 11800, Malaysia. siewchinong@usm.my.ORCID http://orcid.org/0000-0002-9750-9588
Hui Ming OngDepartment of Psychiatry and Mental Health, Hospital Pulau Pinang, Ministry of Health Malaysia, Georgetown, Pulau Pinang, 10990, Malaysia.
Ewe Eow TehDepartment of Psychiatry and Mental Health, Hospital Pulau Pinang, Ministry of Health Malaysia, Georgetown, Pulau Pinang, 10990, Malaysia.
Alan Swee Hock Ch'ngDepartment of Medicine, Seberang Jaya Hospital, Ministry of Health Malaysia, Seberang Perai, Penang, 13700, Malaysia.
Ing Khieng TiongDepartment of Geriatric, Pusat Jantung Sarawak, Ministry of Health Malaysia, Kota Samarahan, Sarawak, 94300, Malaysia.
Rizah Mazzuin RazaliGeriatric Unit, Department of Medicine, Kuala Lumpur Hospital, Ministry of Health Malaysia, Kuala Lumpur, 50586, Malaysia.
Thaigarajan ParumasivamDiscipline of Pharmaceutical Technology, Universiti Sains Malaysia, Georgetown, Pulau Pinang, 11800, Malaysia.

Funding

Kementerian Sains, Teknologi dan Inovasi 305.PFARMASI.614401 and TDF03211038
6 · The paper itself

Abstract

backgroundThere were limited local studies to examine the health-related quality of life (HRQoL) in informal caregivers of patients with Alzheimer’s disease (AD) in Malaysia. This study aimed to evaluate the HRQoL in informal caregivers of AD along with its predictors. MATERIALS AND

methods132 complete responses were obtained from informal caregivers of patients with AD recruited in 4 tertiary hospitals during outpatient visits. Their HRQoL was assessed with the 36-item Short Form Health Survey (SF-36). Sociodemographic of both patients and caregivers were assessed as well as the time spent in informal care via a structured questionnaire. Summary scores of each SF-36 domains, Physical Component Summary (PCS) and Mental Component Summary (MCS) were compared with population norm in Malaysia. Forward stepwise multiple linear regression was conducted to identify significant factors influencing caregivers’ HRQoL.

resultsWith the mean PCS (51.19 ± 9.25) and MCS (44.17 ± 11.19), a declining trend was observed along with increasing disease severity in the study population. Besides the domain of physical functioning, a significant decline was detected in all remaining seven SF-36 domains compared to Malaysia general population. In multivariable models, demand in basic activity of daily living (BADL) (standardised β=-0.25, p = 0.002) and increasing caregivers’ age (standardised β=-0.30, p < 0.001) were negatively correlated with PCS. Female caregivers tend to attain lower PCS (standardised β=-0.19, p = 0.017). Nevertheless, providing care to female patients was related with higher MCS (standardised β = 0.23, p = 0.008). .

conclusionInformal caregivers of patients with AD demonstrated diminished overall well-being regardless of physical or mental aspects. These findings underscore the necessity for support programs that address physical care demands and provide psychosocial interventions, particularly for older and female caregivers.

Indexed as

Alzheimer DiseaseCaregiversQuality of LifeAdultAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMalaysiaMaleMiddle AgedPsychometricsSurveys and QuestionnairesAlzheimerDementiaInformal caregiverQuality of lifeSF-36Well-being

Identifiers

PMID41327116
PMCPMC12777307

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.