Evidence mapPaperPMID 41327471Full record

ArticleEuropean journal of medical research2025

Association of C-reactive protein to albumin ratio with prevalence and mortality in metabolic syndrome: NHANES 1999-2010.

Laicheng Wang, Chennan Liu, Xuan Zheng, Ailing Wang, Yunchai Lin, Feng Peng

Abstract read
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laicheng Wang *Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, China.
Chennan Liu *Department of Cardiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
Xuan ZhengDepartment of Cardiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
Ailing WangDepartment of Cardiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
Yunchai LinDepartment of Cardiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
Feng PengDepartment of Cardiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China. pengfeng@fjmu.edu.cn.

Funding

Joint Funds for the Innovation of Science and Technology, Fujian Province 2021Y9121
6 · The paper itself

Abstract

backgroundMetabolic syndrome (MetS) is closely related to inflammation and oxidative stress. C-reactive protein to albumin ratio (CAR) is an inflammatory and nutritional marker, and this study aims to explore its relationship with the occurrence and prognosis of MetS.

methodsThe study utilized data derived from the National Health and Nutrition Examination Survey 1999-2010. Among the 11,669 adult participants, 4,290 (33%) were diagnosed with MetS. Multivariate logistic regression was employed to investigate the association between CAR and MetS. To assess the impact of CAR on all-cause and cardiovascular mortality among people with MetS, Kaplan-Meier survival curve, Cox proportional risk model, restricted cubic spline, and receiver operating characteristic (ROC) curve were used.

resultsThis study showed that the highest CAR quantile level was strongly association with the prevalence of MetS in the population (OR = 4.92 95% CI 4.19-5.77 P < 0.001). In people with MetS, elevated CAR increased the risk of all-cause death (HR = 1.51 95% CI 1.27-1.79 P < 0.001) and cardiovascular death (HR = 1.65 95% CI 1.29-2.09 P < 0.001). The ROC curve indicated the predictive value of CAR for all-cause death in people with MetS (AUC = 0.64).

conclusionOur findings demonstrate the predictive value of CAR for the prevalence and mortality due to MetS, and highlight the role of inflammation in the development and prognosis of MetS.

Indexed as

C-Reactive ProteinMetabolic SyndromeSerum AlbuminAdultAgedBiomarkersFemaleHumansMaleMiddle AgedNutrition SurveysPrevalencePrognosisRisk FactorsROC CurveBiomarkersC-Reactive ProteinSerum AlbuminC-reactive protein to albumin ratioMetabolic syndromeMortalityPrevalence

Identifiers

PMID41327471
PMCPMC12777314

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.