ArticleClinical endocrinology2026
Cerebrovascular Function in Women With Polycystic Ovary Syndrome: A Pilot Multi-Parameter Magnetic Resonance Imaging Study.
Article in Clinical endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Endocrine modulation of cortical and retinal baseline perfusion across the menstrual cycle.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Cerebrovascular Function in Women With Polycystic Ovary Syndrome: A Pilot Multi-Parameter Magnetic Resonance Imaging Study.Clinical endocrinology · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
objectivePolycystic ovary syndrome (PCOS) is associated with an increased risk of cerebrovascular disease, but the effects on cerebrovascular function are unknown. In this pilot study, we sought to compare cerebrovascular perfusion, pulsatility, reactivity and metabolism between women with PCOS and healthy volunteers using MRI, and investigated the influence of testosterone and insulin resistance on these parameters.
designCase-control pilot study. PATIENTS: Fifteen patients with PCOS (age: 32.0 ± 7.4 years; body mass index [BMI]: 31.8 ± 5.7 kg/m MEASUREMENTS: We used 3T magnetic resonance imaging (MRI) to assess several aspects of cerebrovascular function: (1) perfusion (cerebral blood flow [CBF] and arterial arrival time [AAT]; PCOS N = 15; HC N = 12), (2) pulsatility index (PCOS N = 15; HC N = 12), (3) breath-hold induced cerebrovascular reactivity (CVR; PCOS N = 15; HC N = 10), and (4) global oxygen metabolism (oxygen extraction fraction [OEF] and cerebral metabolic rate of oxygen [CMRO
resultsOverall baseline CBF was not statistically different in PCOS patients compared to controls after adjustment for other variables (χ
conclusionsWe observed regional reduction in cerebral blood flow and regional increase in cerebrovascular reactivity in women with PCOS compared to healthy controls. However, due to the limited statistical power and unclear menstrual timing in this pilot study, these results require further replication.
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