Evidence map›Paper›PMID 41327805›Full record

ArticleHuman vaccines & immunotherapeutics2025

Risk of autoimmune disease flares after recombinant zoster vaccine: A vaccine safety analysis based on the Vaccine Adverse Event Reporting System database.

Geliang Liu, Xinxi Zhang, Yajing Wang, Yang Wang, Peifeng He, Qi Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Geliang LiuShanxi Key Laboratory of Big Data for Clinical Decision, Shanxi Medical University, Taiyuan, China.
Xinxi ZhangShanxi Key Laboratory of Big Data for Clinical Decision, Shanxi Medical University, Taiyuan, China.
Yajing WangShanxi Key Laboratory of Big Data for Clinical Decision, Shanxi Medical University, Taiyuan, China.
Yang WangShanxi Key Laboratory of Big Data for Clinical Decision, Shanxi Medical University, Taiyuan, China.
Peifeng HeInstitute of Medical Data Sciences, Shanxi Medical University, Taiyuan, China.
Qi YuShanxi Key Laboratory of Big Data for Clinical Decision, Shanxi Medical University, Taiyuan, China.ORCID 0000-0001-7796-6899

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since its introduction in 2017, limited research has assessed the risk of flares in patients with autoimmune disease receiving the recombinant zoster vaccine (RZV). Herein, we evaluated the RZV-related flare risk using the Vaccine Adverse Event Reporting System (VAERS), exploring relevant patient characteristics. RZV vaccination records were extracted from VAERS (2017 Q1-2024 Q3), focusing on individuals diagnosed with rheumatoid arthritis (RA), multiple sclerosis (MS), inflammatory bowel disease (IBD), psoriasis, or systemic lupus erythematosus (SLE). RZV-related flare cases were identified using preferred terms and symptom descriptions. Disproportionality analyses, including reporting odds ratio (ROR) and three additional algorithms, were performed. Descriptive analyses assessed clinical characteristics and time to flare onset. A total of 920 patients who received RZV were identified, with a flare incidence of 8.5% (n = 78). Disproportionality analysis showed a positive flare risk signal (ROR, 3.00;

Indexed as

Adverse Drug Reaction Reporting SystemsAutoimmune DiseasesHerpes Zoster VaccineAdolescentAdultAgedAged, 80 and overDatabases, FactualFemaleHerpes ZosterHumansMaleMiddle AgedVaccinationVaccines, SyntheticYoung AdultHerpes Zoster VaccineVaccines, Syntheticautoimmune diseaseflare riskRecombinant zoster vaccinevaccine adverse eventVaccine Adverse Event Reporting System (VAERS)vaccine safety

Identifiers

PMID41327805
PMCPMC12674281

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.