ArticleJournal of advanced veterinary and animal research2025
Quercetin attenuates pentylenetetrazol-induced seizures in chicks through antioxidant and anti-inflammatory pathways.
Article in Journal of advanced veterinary and animal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Anticonvulsant Effects of Citronellal, Daidzin, and Phytol, Possibly Through GABABrain and behavior · 2026Article
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4 authors.
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Abstract
Objective: This study examines the neuroprotective and anticonvulsant effects of quercetin on pentylenetetrazol (PTZ)-induced convulsive seizures in chicks. Materials and Methods: Sixty Ross broiler chicks were randomly assigned to six groups: a negative control, a positive control treated with PTZ at 80 mg/kg, a diazepam-treated group (5 mg/kg), and three quercetin-treated groups receiving 50, 100, and 200 mg/kg orally for six consecutive days, respectively. Two hours after the final dose, PTZ was administered to groups 3-6 to induce seizures. The onset of convulsions and mortality rates were recorded over a period of 3 h. Brain tissue was collected to determine biochemical parameters, malondialdehyde (MDA), total antioxidant capacity (TAO-C), interleukin-1β (IL-1β), and tumor necrosis factor-α ( Results: The delay in the onset of convulsions and survival improvement were found in quercetin pretreatment, in a dose-dependent manner. The highly significant survival was found at 200 mg/kg ( Conclusion: Quercetin pretreatment at 200 mg/kg showed antioxidant and anti-inflammatory potential against PTZ-induced convulsive seizure as a preventive therapy for epilepsy management.
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