ArticleJournal of advanced veterinary and animal research2025
Relationship between oxidative stress and COVID-19 severity: A systematic review and meta-analysis.
Article in Journal of advanced veterinary and animal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: COVID-19 is a complex disease in which the interaction of the SARS-CoV-2 virus with target cells, activation of the immune system, and release of inflammatory cytokines are closely intertwined. Oxidative stress is associated with all of these events, which significantly contribute to the pathogenesis of COVID-19. This study aimed to analyze the relationship quantitatively between oxidative stress and the disease severity in hospitalized patients. Methodology: Articles measuring pro-oxidant and antioxidant markers in patients with COVID-19 were retrieved through the search engines ScienceDirect, PubMed, and Google Scholar. Two authors independently extracted data using the data extraction tool, and a third arbitrator was consulted if consensus was not reached. Data were subjected to meta-analysis using the "meta" package of R programming for forests and the trim and fill method under a random-effects model based on standardized mean differences (SMDs). We tested for heterogeneity in effect size using the Results: Of the 3,103 articles screened, 17 met the inclusion criteria. When comparing control Conclusion: This meta-analysis revealed significantly higher levels of pro-oxidants (H₂O₂ and TOS) and lower levels of antioxidants (SOD, CAT, GSH, and thiols) in severe cases of COVID-19 compared to controls and mild cases, indicating that oxidative stress contributes to the severity of the disease. Assessing pro-oxidant and antioxidant stress markers may help assess disease severity for effective triage of COVID-19 patients. This information will be valuable for a broader discussion on the pathogenesis of COVID-19.
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