ReviewClinical interventions in aging2025
Aging and Intestinal Fibrosis: Mechanisms, Implications, and Therapeutic Strategies.
Review in Clinical interventions in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the global aging population, the impact of aging on various organ systems is becoming increasingly significant. The gastrointestinal tract, a key site of immune activity and microbial colonization, undergoes functional decline that is closely associated with a range of intestinal and systemic diseases. While aging-related fibrosis has been extensively studied in organs such as the lungs, liver, heart, and kidneys, its role in intestinal fibrosis remains underexplored. This review discusses mechanisms by which aging may promote or increase the risk of intestinal fibrosis, including immunosenescence, cellular senescence, gut microbiota dysbiosis, and dysregulated growth factor signaling. Additionally, both traditional and emerging therapeutic strategies are summarized to guide future interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.