Evidence map›Paper›PMID 41328470›Full record

ArticlemAbs2025

A high-throughput platform for biophysical antibody developability assessment to enable AI/ML model training.

Ammar Arsiwala, Rebecca Bhatt, Lood van Niekerk, Porfirio Quintero-Cadena, Xiang Ao, Adam Rosenbaum, Aanal Bhatt, Alexander Smith, Yaoyu Yang, K C Anderson and 18 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mAbs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Ammar ArsiwalaGinkgo Bioworks, Inc., Boston, MA, USA.ORCID 0000-0002-5121-9163
Rebecca BhattGinkgo Bioworks, Inc., Boston, MA, USA.
Lood van NiekerkGinkgo Bioworks, Inc., Boston, MA, USA.ORCID 0000-0001-9082-2574
Porfirio Quintero-CadenaGinkgo Bioworks, Inc., Boston, MA, USA.ORCID 0000-0003-0067-5844
Xiang AoGinkgo Bioworks, Inc., Boston, MA, USA.ORCID 0009-0002-3565-9473
Adam RosenbaumGinkgo Bioworks, Inc., Boston, MA, USA.ORCID 0009-0003-2316-477X
Aanal BhattGinkgo Bioworks, Inc., Boston, MA, USA.ORCID 0000-0002-0534-9274
Alexander SmithGinkgo Bioworks, Inc., Boston, MA, USA.ORCID 0009-0009-3298-4431
Yaoyu YangCypher Technologies Inc., Cambridge, MA, USA.ORCID 0000-0002-5745-3970
K C AndersonGinkgo Bioworks, Inc., Boston, MA, USA.
Lucia GrippoGinkgo Bioworks, Inc., Boston, MA, USA.ORCID 0000-0002-0058-9279
Xing CaoGinkgo Bioworks, Inc., Boston, MA, USA.
Rich CohenGinkgo Bioworks, Inc., Boston, MA, USA.
Jay PatelGinkgo Bioworks, Inc., Boston, MA, USA.
Joshua MollerGinkgo Bioworks, Inc., Boston, MA, USA.
Olga AllenGinkgo Bioworks, Inc., Boston, MA, USA.
Ali FarajGinkgo Bioworks, Inc., Boston, MA, USA.
Anisha NandyAstraZeneca, Waltham, MA, USA.
Jason HockingGinkgo Bioworks, Inc., Boston, MA, USA.
Ayla ErgunGinkgo Bioworks, Inc., Boston, MA, USA.ORCID 0000-0002-7934-1259
Berk TuralGinkgo Bioworks, Inc., Boston, MA, USA.
Sara SalvadorTakeda Pharmaceuticals, Cambridge, MA, USA.
Joe JacobowitzMerida Biosciences, Cambridge, MA, USA.
Kristin SchavenGinkgo Bioworks, Inc., Boston, MA, USA.
Mark ShermanGinkgo Bioworks, Inc., Boston, MA, USA.
Sanjiv ShahRevolution Medicines, Redwood City, MA, USA.
Peter M TessierUniversity of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3220-007X
David W BorhaniGinkgo Bioworks, Inc., Boston, MA, USA.ORCID 0000-0002-8486-8792

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibodies must bind their targets with high affinity and specificity to achieve useful therapeutic activity. They must also possess suitable developability properties (e.g. thermostability, solubility, viscosity, polyreactivity) to ensure favorable manufacturing, formulation, and

Indexed as

Antibodies, MonoclonalHigh-Throughput Screening AssaysMachine LearningHumansAntibodies, MonoclonalAntibodiesbiophysical assaysdevelopabilitymachine learningmanufacturability

Identifiers

PMID41328470
PMCPMC12674332

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.