Evidence mapPaperPMID 41328732Full record

ArticleXenobiotica; the fate of foreign compounds in biological systems2026

Mass balance and metabolite profiling of

Robert B MacArthur, Sem A O F Rikken, Spandana R Vootukuri, Barry S Coller, C Michael Gibson, Christopher B Granger, G Montalescot, Jurriën M Ten Berg, Murray P Ducharme, Arnoud W J van 't Hof

Abstract readClinical Trial, Phase I
In one paragraph

Article in Xenobiotica; the fate of foreign compounds in biological systems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Robert B MacArthurDepartment of Pharmacy Services, Rockefeller University Hospital, New York, NY, USA.ORCID 0000-0002-3264-4666
Sem A O F RikkenDepartment of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.ORCID 0000-0002-4118-9044
Spandana R VootukuriLaboratory of Blood and Vascular Biology, Rockefeller University, New York City, NY, USA.ORCID 0000-0002-4478-712X
Barry S CollerLaboratory of Blood and Vascular Biology, Rockefeller University, New York City, NY, USA.ORCID 0000-0002-9078-7155
C Michael GibsonBoston Clinical Research Institute, Boston, MA, USA.ORCID 0000-0002-4857-9125
Christopher B GrangerDepartment of Cardiology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-0045-3291
G MontalescotSorbonne Université, ACTION Study Group, ICAN-Institut de Cardiologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France.ORCID 0000-0003-0824-6809
Jurriën M Ten BergDepartment of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
Murray P DucharmeLearn and Confirm Inc, Montréal, Canada.
Arnoud W J van 't HofCardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands.ORCID 0000-0002-2344-7564

Funding

Platelet Integrin AlphaIIbBeta3 Structure, Activation, and Ligand Binding: Fibrinogen, Fibrin, D-dimer, and von Willebrand FactorR01HL019278 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · 1985 to 2025
$4.9M
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · ROCKEFELLER UNIVERSITY · 2025 to 2025
$3.7M
NCATS NIH HHS UL1 TR001866NHLBI NIH HHS R01 HL019278
6 · The paper itself

Abstract

The human metabolic and excretion profile of zalunfiban, a novel glycoprotein IIb/IIIa inhibitor, was studied in a phase 1 clinical trial.

Indexed as

AdultCarbon RadioisotopesFemaleHumansInjections, SubcutaneousMaleMiddle AgedCarbon Radioisotopes14C-radiolabeledDrug absorptiondrug excretiondrug metabolismGPIIb/IIIa inhibitormass balancepharmacokineticSTEMIzalunfiban

Identifiers

PMID41328732
PMCPMC13108699

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.