Evidence map›Paper›PMID 41328922›Full record

Trial reportOral health & preventive dentistry2025

Efficacy of a Mouthwash Containing Resveratrol in Reducing Halitosis-related P. gingivalis: A Randomized Triple-blind Trial.

Noor A Abed Taher, Athraa Ali Mahmood, Hashim Mueen Hussein

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Oral health & preventive dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06882564 phase3recruitingnot on this map

Efficacy of Resveratrol Containing Mouthwash in Reducing Halitosis Related Porphyromonas Gingivalis: A Randomized, Triple-blind Clinical Trial

TypeinterventionalSponsorAl-Mustansiriyah UniversityRan2025 to 2025Enrolled54ConditionsHalitosis, Mouth Disease, Plaque Induced Gingival Disease, Bleeding GumArmsresveratrol mouthwash, Chlorhexidine mouthwash (0.2%), Placebo
NCT07393802 phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Biofilm Re-Growth Randomized Crossover Clinical Trial

TypeinterventionalSponsorUniversity of BaghdadRan2026 to 2026Enrolled20ConditionsMouthwash, Chlorhexidine, Biofilm Formation, Periodontal HealthArmsResveratrol-Based Mouthwash, Chlorhexidine Gluconate 0.12 % Mouthwash, Placebo mouthwash
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Noor A Abed Taher
Athraa Ali Mahmood
Hashim Mueen Hussein

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the efficacy of an anti-oxidant and anti-inflammatory RSV-mouthwash in reducing halitosis-related P. gingivalis and clinical periodontal parameters (plaque index [PI], gingival index [GI], and bleeding on probing [BOP]) in undergraduate dental students with plaque-induced gingivitis. MATERIALS AND

methodsThis research was conducted as a randomized, triple-blind clinical trial involving 54 participants who had halitosis associated with plaque-induced gingivitis. Resveratrol (RSV) mouthwash was used by the test group, and 0.2% CHX digluconate mouthwash was used as the positive control. The mouthwash used in the negative control group was distilled water (DW). Clinical parameters, including PI, GI, and BOP, were examined at the baseline appointment and again after one week of using mouthwashes alongside routine oral hygiene measures. Porphyromonas gingivalis was chosen as the target microbe due to its known status as a major pathogen linked to periodontal disease and bad breath. The presence of P. gingivalis was evaluated and compared before and after treatment by real-time PCR. During the last appointment, the participants responded to an mouthwash-assessment questionnaire based on a visual analog scale (VAS). Data description, analysis, and presentation were performed using the SPSS, with the significance level set at p 0.05. This trial was registered at clinicaltrials.gov (NCT06882564).

resultsRSV and CHX statistically significantly reduced halitosis scores, PI, BOP, GI, and the level of P. gingivalis in plaque samples. According to participants' answers to the mouthwash survey, there were no statistically significant differences between RSV and CHX.

conclusionRSV mouthwash has a statistically significant effect on the treatment of P. gingivalis-related halitosis when used as an adjunct to routine oral care. RSV caused a statistically significant decrease in clinical periodontal parameters, including PI, BOP, GI, and halitosis scores, with a statistically significant reduction in the level of P. gingivalis. Thus, RSV shows promising short-term efficacy and warrants further longer-term and larger-scale studies.

Indexed as

AntioxidantsHalitosisMouthwashesPorphyromonas gingivalisResveratrolStilbenesAdultDental PlaqueDental Plaque IndexFemaleGingivitisHumansMalePeriodontal IndexTreatment OutcomeYoung AdultAntioxidantsMouthwashesResveratrolStilbeneschlorhexidinehalitosismouthwashPorphyromonas gingivalisresveratrol.

Identifiers

PMID41328922
PMCPMC12673213

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.