Evidence map›Paper›PMID 41329099›Full record

ArticleACS chemical neuroscience2025

Next-Generation MDMA Analogue SDMA: Pharmacological and Metabolic Insights.

Nina Kastner, Núria Nadal-Gratacós, Selina Hemmer, Leticia Alves da Silva, John L McKee, Tamara Hell, Giulia Cicalese, Marion Holy, Fatemeh Kooti, Kathrin Jäntsch and 10 more

Erratum issuedAbstract read
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In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Nina KastnerInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria.ORCID 0000-0002-1576-9029
Núria Nadal-GratacósDepartment of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy, Pharmacology Section and Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08028, Spain.ORCID 0000-0002-9791-249X
Selina HemmerExperimental and Clinical Toxicology and Pharmacology, Center for Molecular Signaling (PZMS), PharmaScienceHub (PSH), Saarland University, Homburg 66424, Germany.
Leticia Alves da SilvaInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria.
John L McKeeDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.ORCID 0009-0003-7988-8646
Tamara HellMiHKAL GmbH, Stansstad 6362, Switzerland.
Giulia CicaleseDepartment of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy, Pharmacology Section and Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08028, Spain.
Marion HolyInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria.
Fatemeh KootiInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria.
Kathrin JäntschInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria.
Ricarda BaronInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria.
Naomi ShachamDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0021, United States.
Bruna CuccurazzuDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0021, United States.
Adam L HalberstadtDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0021, United States.
John D McCorvyDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.ORCID 0000-0001-7555-9413
Thomas StocknerInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria.ORCID 0000-0002-7071-8283
Markus R MeyerExperimental and Clinical Toxicology and Pharmacology, Center for Molecular Signaling (PZMS), PharmaScienceHub (PSH), Saarland University, Homburg 66424, Germany.ORCID 0000-0003-4377-6784
Raúl López-ArnauDepartment of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy, Pharmacology Section and Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08028, Spain.ORCID 0000-0001-8904-7398
Matthias GrillMiHKAL GmbH, Stansstad 6362, Switzerland.
Harald H SitteInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria.ORCID 0000-0002-1339-7444

Funding

Structure-based Design of Selective Serotonin Biased Agonists as Chemical Probes for Psychedelic PotentialR01MH133849 · NIMH · MEDICAL COLLEGE OF WISCONSIN · PI John D McCorvy · 2023 to 2026
$2.1M
NIMH NIH HHS R01 MH133849
6 · The paper itself

Abstract

3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, shows promise in treating depression and post-traumatic stress disorder (PTSD), resulting in breakthrough status. However, concerns regarding MDMA's abuse potential and cytotoxicity have sparked interest in developing safer analogues with similar therapeutic benefits. This study investigated the pharmacological properties of MDMA analogues in which the 1,3-benzodioxole group is replaced by a 1,3-benzoxathiole, termed SDA and SDMA, compared to MDA and MDMA through

Indexed as

N-Methyl-3,4-methylenedioxyamphetamineAnimalsDopamine Plasma Membrane Transport ProteinsHallucinogensHEK293 CellsHumansMaleMiceMice, Inbred C57BLMolecular Docking SimulationNorepinephrine Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport ProteinsDopamine Plasma Membrane Transport ProteinsHallucinogensN-Methyl-3,4-methylenedioxyamphetamineNorepinephrine Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport Proteinsanalogueshepatic metabolismMDMAmonoamine receptorsmonoamine transporterspharmacological profile

Identifiers

PMID41329099
PMCPMC12715756

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.