Evidence map›Paper›PMID 41329158›Full record

ArticleeLife2025

Tim Casey-Clyde, S John Liu, Angelo Pelonero, Juan Antonio Camara Serrano, Camilla Teng, Yoon-Gu Jang, Harish N Vasudevan, Arun Padmanabhan, Jeffrey Ohmann Bush, David R Raleigh

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. eLife · 2025
    Article
4 · The record

Corrections and comments

  • Update of
    2025
5 · Who and what money

Authors and funding

10 authors.

Tim Casey-ClydeDepartment of Radiation Oncology, University of California San Francisco, San Francisco, United States.
S John LiuDepartment of Radiation Oncology, University of California San Francisco, San Francisco, United States.
Angelo PeloneroGladstone Institutes, San Francisco, United States.
Juan Antonio Camara SerranoHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States.
Camilla TengDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, United States.
Yoon-Gu JangDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, United States.
Harish N VasudevanDepartment of Radiation Oncology, University of California San Francisco, San Francisco, United States.
Arun PadmanabhanDepartment of Medicine, Division of Cardiology, University of California San Francisco, San Francisco, United States.
Jeffrey Ohmann BushDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, United States.ORCID https://orcid.org/0000-0002-6053-8756
David R RaleighDepartment of Radiation Oncology, University of California San Francisco, San Francisco, United States.ORCID https://orcid.org/0000-0001-9299-8864

Funding

Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Signaling control and cellular basis of craniofacial morphogenesis and congenital diseaseR35DE031926 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeffrey Ohmann Bush · 2022 to 2026
$5.2M
Biochemical mechanisms of Hedgehog signal transduction through primary ciliaR21HD106238 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RALEIGH, DAVID R · 2022 to 2023
$444k
Department of Defence NFRP NF200021NCI NIH HHS T32 CA151022NICHD NIH HHS R21 HD106238NIDCR NIH HHS R35 DE031926NIH HHS R21 HD106238NIH HHS R35 DE031926NIH HHS T32 CA151022
6 · The paper itself

Abstract

The histone methyltransferase Polycomb repressive complex 2 (PRC2) is required for specification of the neural crest, and mis-regulation of neural crest development can cause severe congenital malformations. PRC2 is necessary for neural crest induction, but the embryonic, cellular, and molecular consequences of PRC2 activity after neural crest induction are incompletely understood. Here, we show that

Indexed as

Cell DifferentiationCell ProliferationMesodermNeural CrestOsteoblastsPolycomb Repressive Complex 2AnimalsCraniofacial AbnormalitiesEpigenesis, GeneticGene Expression Regulation, DevelopmentalMiceMice, KnockoutOsteogenesisSkullEed protein, mousePolycomb Repressive Complex 2chromatincraniofacial developmentdevelopmental biologyepigeneticsmesenchymalmouseosteoblastssingle-cell sequencing

Identifiers

PMID41329158
PMCPMC12671911

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.