Article in The Journal of cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors.
Martina Lerche *Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.ORCID 0000-0002-8203-1120
Mathilde Mathieu *Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.ORCID 0000-0002-9304-9692
Hellyeh HamidiTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.ORCID 0000-0003-4841-8927
Megan ChastneyTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.ORCID 0000-0002-9866-2322
Guillaume JacquemetTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.ORCID 0000-0002-9286-920X
Bart Marlon Herwig BruininksDepartment of Physics, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-5136-0864
Shreyas KaptanDepartment of Physics, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-1265-4557
Lene MalerødDepartment of Molecular Cell Biology, Institute for Research, Oslo University Hospital, Montebello, Norway.ORCID 0000-0001-9075-3652
Nina Marie PedersenDepartment of Molecular Cell Biology, Institute for Research, Oslo University Hospital, Montebello, Norway.ORCID 0009-0006-8016-5922
Andreas BrechDepartment of Molecular Cell Biology, Institute for Research, Oslo University Hospital, Montebello, Norway.ORCID 0000-0002-9803-1774
Nobuyuki MatobaDepartment of Pharmacology and Toxicology, Brown Cancer Center, and Center for Predictive Medicine, University of Louisville School of Medicine, Louisville, KY, USA.ORCID 0000-0001-7231-3004
Yuichiro SatoDepartment of Medical Pharmacy, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.ORCID 0000-0001-9992-4753
Ilpo VattulainenDepartment of Physics, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-7408-3214
Pere Roca-CusachsInstitute for Bioengineering of Catalonia (IBEC) , The Barcelona Institute of Technology (BIST), Barcelona, Spain.ORCID 0000-0001-6947-961X
Franck PerezIntracellular Transport: Engineering and Mechanisms Laboratory, PSL Research University, Sorbonne Université, Centre National de la Recherche Scientifique, Institut Curie, Paris, France.ORCID 0000-0002-9129-9401
Gaelle BoncompainIntracellular Transport: Engineering and Mechanisms Laboratory, PSL Research University, Sorbonne Université, Centre National de la Recherche Scientifique, Institut Curie, Paris, France.ORCID 0000-0003-4274-035X
Stéphanie MisereyIntracellular Transport: Engineering and Mechanisms Laboratory, PSL Research University, Sorbonne Université, Centre National de la Recherche Scientifique, Institut Curie, Paris, France.ORCID 0000-0003-4994-0258
Johanna IvaskaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.ORCID 0000-0002-6295-6556
Funding
Åbo Akademi UniversityÅbo Akademi University Research FoundationEuropean Molecular Biology Organization ALTF 798-2021European Research Council 101097753Finnish Cancer InstituteFinnish Cancer OrganizationFoundation for the Finnish Cancer InstituteHelsinki Institute of Life Science (HiLIFE)Human Frontier Science Program RGP0059/2019ICREA AcademiaK. Albin Johanssons StiftelseMarie Curie Skłodowska fellowship schemeNorwegian Cancer SocietyResearch Council of Finland 325464Research Council of Finland 331349Research Council of Finland 335527Research Council of Finland 338537Research Council of Finland 343239Research Council of Finland 346131Research Council of Finland 346135Sigrid Juselius FoundationSpanish Ministry of Science and Innovation PID2022-142672NB-I00Svenska KulturfondenTurku Doctoral Programme of Molecular MedicineVictoriastiftelsen
6 · The paper itself
Abstract
Constitutive integrin endocytosis and recycling control cell movement and morphology. In contrast, the role of newly synthesized integrins delivered via the biosynthetic pathway has been largely overlooked. We used the retention using selective hooks system to monitor the localization of new integrins exiting the endoplasmic reticulum in space and time. We discovered that new integrin delivery to the plasma membrane is polarized and enhances cell protrusion and focal adhesion growth in an extracellular matrix-ligand-dependent manner. Motor-clutch modeling explained the increased adhesion as higher integrin availability driving recruitment of additional receptors. Unexpectedly, live-cell imaging revealed a small subset of fast-emerging integrin vesicles rapidly transported to the cell surface to facilitate localized spreading. This unconventional secretion depended on cell adhesion and correlated with increased surface levels of immature, high-mannose glycosylated integrin, indicating bypass of the canonical Golgi-dependent secretory pathway. Thus, spatial plasma membrane-targeting of new integrins rapidly alters adhesion receptor availability, providing cells with added plasticity to respond to their environment.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway. · full record | Socratic