ArticleEuropean journal of applied physiology2026
Involvement of the PINK1/PARKIN pathway in enhancing mitochondrial function and mitophagy in reserpine-induced fibromyalgia mice through strength exercise and coenzyme Q10.
Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Physical exercise as a precision strategy for targeted PINK1 recruitment- a mechanistic review.Frontiers in physiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the impact of reserpine-induced fibromyalgia and evaluate the potential effects of resistance exercise or CoQ10 administration on muscle strength, structure, and expression of mitochondrial markers in adult mice. Central to this investigation is an exploration of the molecular mechanisms underlying mitophagy via the PINK1/Parkin pathway.
methodsThis study sought to elucidate the Impact of 4 weeks of either climbing exercise or coenzyme Q10 (CoQ10) supplementation (10 mg/kg, administered once daily) on skeletal muscle and mitochondrial functions within a reserpine-induced fibromyalgia (FM) mouse model. Evaluation encompassed the assessment of key mitochondrial markers, including PTEN-induced kinase 1 (PINK1), PARKIN, Mitofusion2, cytochrome c oxidase, citrate synthase, and fibronectin type III domain-containing protein 5 (FNDC5), alongside morphological examinations of the gastrocnemius muscle.
resultsClimbing exercise significantly improved fibromyalgia (FM)-like symptoms and enhanced the expression of mitochondrial marker genes in the gastrocnemius muscle. Histological and ultra-structural studies showed nearly normal muscle fiber structure, banding patterns, mitochondria shape and size, and a notable reduction in collagen fibrosis compared to FM. CoQ10 supplementation also improved mitochondrial gene expression but did not significantly affect FNDC gene expression. Ultrastructural analysis revealed mostly normal muscle fibers with regular banding, though some areas showed disturbances with multiple sub-sarcolemmal and interfibrillar mitochondria.
conclusionThis study underscores the efficacy of both resistance exercise and CoQ10 supplementation as viable strategies for improving FM-related symptoms and enhancing mitochondrial function in mice.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.