Evidence map›Paper›PMID 41329359›Full record

ArticleTropical animal health and production2025

Dietary Houttuynia cordata Thunb attenuates redox imbalance and inflammation possibly induced by heat stress in dairy cows associated with altered fecal microbiota and metabolomics profile.

Lunjie Feng, Hongyu Yi, Zhaoxi Xie, Pan Zhou, Yong Zhang, Ling Cheng, Shuai Chen, Liwen Chen, Chengquan Jiang, Hui Diao and 1 more

Abstract read
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In one paragraph

Article in Tropical animal health and production, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lunjie FengCollege of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621000, China.
Hongyu YiCollege of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621000, China.
Zhaoxi XieCollege of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621000, China.
Pan ZhouCollege of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621000, China.
Yong ZhangCollege of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621000, China.
Ling ChengSichuan College of Traditional Chinese Medicine, Mianyang, Sichuan, 621000, China.
Shuai ChenHongfeng Dairy Cattle Farming Limited Company, Mianyang, Sichuan, 621000, China.
Liwen ChenHongfeng Dairy Cattle Farming Limited Company, Mianyang, Sichuan, 621000, China.
Chengquan JiangSichuan College of Traditional Chinese Medicine, Mianyang, Sichuan, 621000, China. 150315691@qq.com.
Hui DiaoCollege of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621000, China.
Honglin YanCollege of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621000, China. honglinyan@swust.edu.cn.

Funding

Sichuan Science and Technology Program 2022YFH0063the Local Science and Technology Development 2022ZYDF081
6 · The paper itself

Abstract

This trial tested the effects of Houttuynia cordata (HC) feeding on lactation performance, redox status, and inflammatory response of heat stress (HS)-suffered dairy cows. Twenty dairy cows were assigned into two dietary treatments, which were offered a basal TMR diet or a diet containing 2% HC for a 35-day trial, during which the average temperature and humidity index was 76.57 ± 0.22 (> 72), indicating a possible exposure to HS. The results showed that HC intake reduced the respiratory rate and rectal temperature, elevated the milk yield, and increased the concentrations of glucose, total phenolic compounds, and total flavonoids and catalase activity in serum of HS-suffered cows (p < 0.05). HC consumption reduced serum insulin, malondialdehyde, diamine oxidase activity, and lipopolysaccharides concentration, as well as lipopolysaccharide-binding protein and interleukin-1β concentrations in the serum and milk of cows. (p < 0.05). Plasma metabolome demonstrated that HC intake increased the concentrations of microbial tryptophan catabolites and reduced the levels of acylcarnitine (p < 0.05). Fecal microbiota sequencing showed that HC ingestion elevated the microbial alpha diversity, indicative of higher Chao1, Shannon, and observed species in feces of cows (p < 0.05). Dietary HC inclusion altered the abundances of certain taxa, like phylum Verrucomicrobiota and genus Akkermansia, in feces of dairy cows (p < 0.05). Network analysis indicated that long-chain acylcarnitines were negatively correlated with Prevotellaceae_UCG-004 and Akkermansia (p < 0.05). Overall, HC intake alleviated thermal stress-induced performance impairment, redox imbalance, and inflammation, possibly via altering fecal microbiome and plasma metabolite profile in cows.

Indexed as

Cattle DiseasesGastrointestinal MicrobiomeHeat-Shock ResponseHeat Stress DisordersHouttuyniaInflammationAnimal FeedAnimalsCattleDietDietary SupplementsFecesFemaleLactationMetabolomeOxidation-ReductionDairy cowsHeat stressHouttuynia cordataMetabolomicsMicrobiome

Identifiers

PMID41329359

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.