Evidence map›Paper›PMID 41329628›Full record

ArticleLupus2026

Exploring prefrontal alpha modulation as a mechanistic treatment target in lupus-associated depression: A transcranial alternating current stimulation study.

Magdalena Camenzind, Tobias Schwippel, Shruti Saxena-Beem, Yueh Z Lee, Anthony Trujillo, Roger Huamani, Justin Riddle, Agnieszka Zuberer, Flavio Frohlich, Saira Z Sheikh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lupus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Magdalena CamenzindDepartment of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-3125-0710
Tobias SchwippelDepartment of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-8537-222X
Shruti Saxena-BeemUNC Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yueh Z LeeDepartment of Radiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Anthony TrujilloUNC Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Roger HuamaniUNC Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Justin RiddleDepartment of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Agnieszka ZubererDepartment of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Flavio FrohlichDepartment of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Saira Z SheikhUNC Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-4128-0443

Funding

North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
NCATS NIH HHS UM1 TR004406
6 · The paper itself

Abstract

ObjectiveThis study explored whether modulating prefrontal alpha oscillations using transcranial alternating current stimulation (tACS) could alleviate depressive symptoms in individuals with systemic lupus erythematosus (SLE).MethodsOver the course of 5 days, three individuals underwent daily 40-min sessions of 2 mA bifrontal individual alpha frequency tACS (IAF-tACS) while watching a relaxing video. Resting-state 128-channel electroencephalography (EEG) was recorded on Day 1 and Day 5 before each tACS session. Self-reported assessments of depression, anxiety, insomnia, and fatigue were administered on Day 1, Day 5, and at the 2- and 4-week follow-ups.ResultsTwo out of three participants showed a reduction in left prefrontal alpha power after 5 days of IAF-tACS. Only those with this reduction reported short-term improvements in depression, insomnia, anxiety, and well-being.ConclusionThese preliminary results suggest that modulating prefrontal alpha oscillations through tACS may offer a potential approach for alleviating depressive symptoms in individuals with SLE.

Indexed as

Alpha RhythmDepressionLupus Erythematosus, SystemicPrefrontal CortexTranscranial Direct Current StimulationAdultAnxietyElectroencephalographyFemaleHumansMaleMiddle AgedTreatment Outcomeautoimmune diseasedepressionsystemic lupus erythematosusTranscranial alternating current stimulation (tACS)

Identifiers

PMID41329628
PMCPMC12701088

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.