ArticleACS applied bio materials2025
An Anti-Inflammatory and Pro-Angiogenic Porous Aloe Polysaccharide-Collagen Dressing Accelerates Wound Healing.
Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Natural Polysaccharide-Based Biomaterials for Skin Wound Healing: Immunomodulatory Mechanisms and Macrophage M2 Polarization.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proper wound dressing is essential for ensuring and promoting effective wound healing. This study aimed to develop a novel porous composite wound dressing composed of aloe polysaccharide and collagen. The physical properties of aloe polysaccharide-collagen wound dressing (AP-CD) formulated in this study was characterized by scanning electron microscopy, energy dispersive spectroscopy, water absorption and air permeability tests. The safety and cytocompatibility of AP-CD were evaluated using CCK-8 and lactate dehydrogenase leakage rate assays. Besides, the effectiveness of AP-CD was assessed by measuring the wound healing rate. In vivo studies confirmed that AP-CD improved the wound healing rate and accelerated the healing process. Furthermore, AP-CD suppressed inflammatory response, promoted angiogenesis, increased the levels of growth factors and anti-inflammatory factors, and decreased the levels of pro-inflammatory factors. Single-cell sequencing analysis revealed a significant increase in the proportion of macrophages and T lymphocytes in AP-CD-treated wound tissue, accompanied by a notable decrease in fibroblast proportions. In summary, AP-CD demonstrated superior physical and chemical properties, good biocompatibility, and safety, making it a viable option for wound dressing. In vivo studies indicated that AP-CD effectively inhibited inflammatory responses and enhanced angiogenesis, thereby accelerating wound healing.
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Registered trials
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