ArticleCell host & microbe2025
Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance.
Article in Cell host & microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Microbiome-based therapeutics forGut microbes · 2026Review
- The Nexus of Gut Microbiome, Microbial Metabolites, and Colonization Resistance Against Enteric Pathogens.Biomolecules · 2026Review
- Antibiotic-induced gut microbiome dysbiosis: risks and strategies for mitigation.The EMBO journal · 2026Review
- Enhancements of symbiotic adhesion and antibiotic efficacy observed by the metabolic crosstalk within cell-bacteria cocultured on a microfluidic gut chip.Journal of pharmaceutical analysis · 2026Article
- Comparative metagenomic characterization of gut microbiota and antibiotic resistome in multi-facility SPF mice.BMC microbiology · 2026Article
- Precision microbiome medicine and therapeutics: the enabling role of in vitro gut models.FEMS microbiology reviews · 2026Review
- Gut microbiota and SCFA signatures in predicting postoperative infection sites in neurocritical care patients.Frontiers in microbiology · 2026Article
- Bioinformatic Analysis of Oxalate-Degrading Enzymes in Probiotics: A Systematic Genome-Scale and Structural Survey.Microorganisms · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
A subset of commensal bacterial strains secretes bacteriocins, such as lantibiotics, to inhibit or kill neighboring bacteria, thereby protecting their niche in the gut. The antimicrobial spectrum of lantibiotics includes pathogens, offering a potential therapeutic approach for antibiotic-resistant infections. However, the impact of lantibiotic-producing bacteria on the microbiome remains poorly defined. We find that bacterial species encoding lanthipeptide genes in hospitalized patients are present in greater abundance than lantibiotic-deficient strains of the same species. Among the lanthipeptide sequences, some overlapped with the lantibiotic genes of Blautia pseudococcoides SCSK (BpSCSK). In mice, BpSCSK administration prevents intestinal recolonization by a wide range of commensal species following antibiotic-induced dysbiosis and markedly reduces fecal concentrations of microbiota-derived metabolites. Lantibiotic-mediated dysbiosis results in sustained loss of colonization resistance against Klebsiella pneumoniae and Clostridioides difficile infection. Our findings reveal the impact of lantibiotic-producing bacterial species on microbiome resilience and susceptibility to infection following antibiotic treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.