ArticleScientific reports2025
mRNA expression of DNA methylation machinery genes in periapical granuloma and their potential relationship with periapical wound healing.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Improbable healing in endodontics: a case series of favorable outcomes despite adverse prognostic conditions.BMC oral health · 2026Article
- Increased TET3 expression associates with proinflammatory cytokines and reduced 5-hydroxymethylcytosine in periapical lesions.Clinical oral investigations · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
This study was designed to explore the relative expression of DNA methylation machinery genes in periapical granuloma and to assess longitudinal changes in gene expression within the healing group at 6 and 12 months. A total of twenty-seven patients (13 chronic apical periodontitis and 14 chronic apical abscess) underwent surgical endodontic treatment. During surgical endodontic treatment, periapical lesion tissue was collected and used for relative expression analysis of the following DNA methylation machinery genes: DNMT-1, TDG, TET-1, TET-2, and TET-3. These patients were subsequently re-appointed after 6 and 12 months for the evaluation of the periapical healing based on the established clinical and radiographic criteria. Quantitative PCR (qPCR) was employed for gene-expression analysis. Statistical analysis was performed using unpaired t-tests and a p-value < 0.05 was considered statistically significant. Post-operative healing was observed in 21 out of 27 patients (77.8%) after 12 months, whereas 6 patients (22.3%) showed no signs of healing at the end of the follow-up period. A statistically significant difference was observed in the expression of the TET-3 genes in chronic apical abscess. Moreover, TDG, TET-2, and TET-3 exhibited a positive fold change in healed chronic apical abscess samples (H + 12 M and H + 6 M) compared to non-healed (NH) samples. The significant differences in the expression of TET-3 gene, may suggest their potential role as epigenetic markers warranting further validation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.