Evidence map›Paper›PMID 41331125›Full record

ArticleCellular and molecular life sciences : CMLS2025

LINC02878/ZNF282/PYCR2 axis promotes proline synthesis and tumor progression in colorectal cancer.

Jun-Ping Lei, Lin Wang, Tian-Yang Wang, Bing-Hu Lin, Yan Xu, Song Shang, Tian Xia, Min-Ming Gong, Yu Guo, Jia Fu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jun-Ping Lei *Department of Colorectal and Anal Surgery, Hubei University of Medicine, Xiangyang No.1 People's Hospital, Xiangyang, 441000, China.
Lin Wang *Department of Gastroenterology, People's Hospital, Hubei University of Medicine, Xiangyang No.1, Xiangyang, 441000, China.
Tian-Yang Wang *Department of Colorectal and Anal Surgery, Hubei University of Medicine, Xiangyang No.1 People's Hospital, Xiangyang, 441000, China.
Bing-Hu LinDepartment of Colorectal and Anal Surgery, Hubei University of Medicine, Xiangyang No.1 People's Hospital, Xiangyang, 441000, China.
Yan XuDepartment of Colorectal and Anal Surgery, Hubei University of Medicine, Xiangyang No.1 People's Hospital, Xiangyang, 441000, China.
Song ShangDepartment of Colorectal and Anal Surgery, Hubei University of Medicine, Xiangyang No.1 People's Hospital, Xiangyang, 441000, China.
Tian XiaDepartment of Colorectal and Anal Surgery, Hubei University of Medicine, Xiangyang No.1 People's Hospital, Xiangyang, 441000, China.
Min-Ming GongDepartment of Colorectal and Anal Surgery, Hubei University of Medicine, Xiangyang No.1 People's Hospital, Xiangyang, 441000, China.
Yu Guo *Department of Colorectal and Anal Surgery, Hubei University of Medicine, Xiangyang No.1 People's Hospital, Xiangyang, 441000, China. G_Yu1982032@126.com.
Jia Fu *Department of Pulmonary and Critical Care Medicine, People's Hospital, Hubei University of Medicine, Xiangyang No.1, Xiangyang, 441000, China. JiaFu_xyyy@yeah.net.
Yuan-Lin Li *Department of Medical Insurance Price Management Office, People's Hospital, Hubei University of Medicine, Xiangyang No.1, Xiangyang, 441000, China. Yuanlin_Li@yeah.net.ORCID http://orcid.org/0009-0005-2323-2626

Funding

innovative Research Program of Xiangyang No.1 People's Hospital XYY2023QA09
6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, with poor survival outcomes in advanced stages due to therapy resistance and metastasis. While long non-coding RNAs (lncRNAs) are emerging as key regulators of CRC progression, their functional interplay and metabolic implications remain poorly understood. Here, we identified LINC02878 as a novel oncogenic lncRNA significantly upregulated in CRC and correlated with poor prognosis. Mechanistically, LINC02878 binds to the ZNF282 to activate PYCR2 expression, thereby enhancing proline biosynthesis and driving tumor aggressiveness. In vivo, LINC02878 knockdown suppressed subcutaneous tumor growth, reduced lung metastasis, and improved survival in xenograft models. Our study unveils the LINC02878/ZNF282/PYCR2/proline axis as a critical metabolic vulnerability in CRC, offering potential therapeutic targets for intervention.

Indexed as

Colorectal NeoplasmsProlineRNA, Long NoncodingAnimalsCell Line, TumorCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, Inbred BALB CMice, NudePrognosisProlineRNA, Long NoncodingColorectal cancerLINC02878Proline synthesisPYCR2ZNF282

Identifiers

PMID41331125
PMCPMC12775219

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.