Evidence map›Paper›PMID 41331534›Full record

ArticleThe EMBO journal2026

E3 ligase AREL1 controls perinuclear localization of lysosomes and supports Purkinje cell survival.

Luyi Jiang, Jiangfen Tang, Ya-Fen Zhang, Wen-Xuan Zou, Gang Deng, Na Tian, Xiaolu Zhao, Lei Han, Kai Liu, Bao-Liang Song and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Luyi JiangState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.
Jiangfen TangState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.
Ya-Fen ZhangState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.
Wen-Xuan ZouState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.
Gang DengState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.
Na TianState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.
Xiaolu ZhaoState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.ORCID http://orcid.org/0000-0003-1535-3880
Lei HanState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.
Kai LiuState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.
Bao-Liang SongState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.ORCID http://orcid.org/0000-0002-6397-5935
Jie LuoState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China. jieluo@whu.edu.cn.ORCID http://orcid.org/0000-0003-1899-3111

Funding

111 Project of Ministry of Education of China B16036National Key R&D Program of China 2024YFA1802801National Natural Science Foundation of China 32021003National Natural Science Foundation of China 32293203National Natural Science Foundation of China 32400564National Natural Science Foundation of China 92354301Natural Science Foundation of Hubei Province 2023AFA050Natural Science Foundation of Hubei Province 2025AFA001
6 · The paper itself

Abstract

Localization of lysosomes influences their properties, e.g., perinuclear lysosomes are more acidic but less mobile compared with the peripheral ones. Furthermore, the endoplasmic reticulum (ER) can actively regulate the dynamics and functions of lysosomes via membrane contact sites. In this study, we find that ER-resident apoptosis-resistant E3 ubiquitin protein ligase 1 (AREL1) establishes membrane contacts with lysosomes by directly interacting with the V

Indexed as

LysosomesPurkinje CellsUbiquitin-Protein LigasesAnimalsCell SurvivalEndoplasmic ReticulumHumansMiceMice, KnockoutUbiquitinationVacuolar Proton-Translocating ATPasesUbiquitin-Protein LigasesVacuolar Proton-Translocating ATPasesAREL1Lysosomal PositioningPurkinje NeuronsUBAC2V-ATPase

Identifiers

PMID41331534
PMCPMC12864862

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.