ArticleClinical, cosmetic and investigational dermatology2025
A Prospective Study on the Efficacy and Safety of the Bipolar Radiofrequency with Multi-Channel and Vacuum-Assisted for Rejuvenation in Periorbital Area.
Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Introduction: The periorbital region is highly susceptible to aging, manifesting as wrinkles, skin laxity, and under-eye bags due to collagen loss and fat displacement. Vacuum-assisted multi-frequency bipolar radiofrequency (RF) offers precise energy delivery, effectively stimulating collagen remodeling while ensuring safety and patient comfort. Objective: This study aimed to evaluate the efficacy and safety of a bipolar RF device with channeling optimized RF energy (CORE™) technology and vacuum assistance for periorbital rejuvenation. Patients and Methods: A prospective, single-center trial enrolled 28 participants (18-60 years), receiving four treatments at three-week intervals. Efficacy was assessed through Fitzpatrick Wrinkle Scale (FWS), Investigator Global Assessment (IGA) scores, and objective skin parameters (hydration, elasticity, gloss), alongside participant self-assessments. Safety was evaluated via adverse events (AEs) and pain scores (VAS). Results: Among 22 participants who completed the study, 95.46% achieved ≥25% improvement in FWS scores (mean reduction: -1.55 ± 0.50), with significant wrinkle reduction from the second treatment (p < 0.001). IGA scores showed visible improvement in under-eye bags, while skin hydration and elasticity increased. About 90.91% of participants reported high satisfaction, and 91.3% rated pain ≤1, with no AEs reported. The total observation period was approximately 12 weeks, including four treatment sessions and a three-week follow-up after the final session. Conclusion: Bipolar RF treatment with CORE technology and vacuum assistance is a safe and effective non-invasive modality for improving periorbital wrinkles and under-eye bags. By promoting collagen remodeling and skin tightening, this technology offers significant clinical and aesthetic benefits with minimal discomfort and no adverse events.
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