Evidence map›Paper›PMID 41332521›Full record

ArticlebioRxiv : the preprint server for biology2025

Phosphorylation remodels the mitotic centrosome matrix to generate bipartite γ-tubulin complex docking sites.

Midori Ohta, Orie Arakawa, Yajie Gu, Wanying Tian, Kevin D Corbett, Arshad Desai, Karen Oegema

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Midori OhtaOkinawa Institute of Science and Technology Graduate University, Okinawa, Japan.ORCID 0000-0001-8189-6846
Orie ArakawaOkinawa Institute of Science and Technology Graduate University, Okinawa, Japan.ORCID 0000-0002-7823-5913
Yajie GuDepartment of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-1514-1477
Wanying TianDepartment of Cell & Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA.ORCID 0000-0002-6038-0725
Kevin D CorbettDepartment of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5854-2388
Arshad DesaiDepartment of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-5410-1830
Karen OegemaDepartment of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-8515-7514

Funding

Kinetochore Specification and FunctionR01GM074215 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DESAI, ARSHAD · 2005 to 2025
$8.2M
Analysis of Centrosome DynamicsR01GM074207 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OEGEMA, KAREN F · 2006 to 2025
$6.6M
Molecular mechanisms of nucleic acid recognition and maintenance in meiosis and innate immunityR35GM144121 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett · 2022 to 2026
$2.7M
NIGMS NIH HHS R01 GM074207NIGMS NIH HHS R01 GM074215NIGMS NIH HHS R35 GM144121
6 · The paper itself

Abstract

Mitotic centrosomes consist of centrioles surrounded by a proteinaceous matrix that docks and activates γ-tubulin complexes (γTuCs) to nucleate microtubules for spindle assembly. During mitotic entry, phosphorylation at centrosomes remodels CDK5RAP2 family matrix proteins to generate γTuC docking sites. We address the mechanism of this conversion using

Identifiers

PMID41332521
PMCPMC12667865

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.