Evidence map›Paper›PMID 41332678›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular mechanism by which SARS-CoV-2 Orf9b suppresses the Tom70-Hsp90 interaction to evade innate immunity.

Noah Sherer, Abhishek Bastiray, Xiao-Ru Chen, Trivikram Molugu, Gaya P Yadav, Tatyana I Igumenova, Jae-Hyun Cho

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Noah ShererDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, United States.
Abhishek BastirayDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, United States.
Xiao-Ru ChenDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, United States.
Trivikram MoluguDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, United States.
Gaya P YadavDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, United States.
Tatyana I IgumenovaDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, United States.
Jae-Hyun ChoDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, United States.

Funding

Structural and Functional Studies of Protein Kinase C RegulationR01GM108998 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI Tatyana I. Igumenova · 2014 to 2026
$3.3M
Mechanistic bases of strain-specific virus-host interactionsR35GM152007 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI Jae Hyun Cho · 2024 to 2026
$1.1M
NIGMS NIH HHS R01 GM108998NIGMS NIH HHS R35 GM152007
6 · The paper itself

Abstract

The Tom70-Hsp90 interaction is critical for activating MAVS-mediated interferon (IFN) production. Upon RNA virus infection, cytosolic Hsp90 recruits key innate immune signaling proteins to MAVS on mitochondria through its interaction with Tom70. To evade this innate immune response, the SARS-CoV-2 protein Orf9b binds to Tom70, thereby disrupting the Tom70-Hsp90 interaction and suppressing IFN production. Despite its importance, the molecular mechanism underlying Orf9b-mediated inhibition of IFN signaling remains unclear. Here, using an integrative approach combining cryo-electron microscopy,

Identifiers

PMID41332678
PMCPMC12667937

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.