Evidence map›Paper›PMID 41332769›Full record

ArticlebioRxiv : the preprint server for biology2025

Computational design of metalloproteases.

Anqi Chen, Kejia Wu, Hojae Choi, Preetham Venkatesh, Samuel J Pellock, Nikita Hanikel, Brian Coventry, Donghyo Kim, Seth M Woodbury, Pengfei Ji and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Anqi ChenDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-9857-0594
Kejia WuDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-4532-4290
Hojae ChoiDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Preetham VenkateshDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-0089-9365
Samuel J PellockDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-7557-7985
Nikita HanikelDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-3292-5070
Brian CoventryDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-6910-6255
Donghyo KimDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-8097-3675
Seth M WoodburyDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-0510-8240
Pengfei JiDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-8109-7929
Shingo HondaDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-9403-6631
Xinting LiDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-5559-7578
Stacey GerbenDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-0313-6248
Lemuel ChangDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0009-0008-7785-5388
Xiao YanMax Planck Institute of Molecular Cell Biology and Genetics; Dresden, Saxony, 01307, Germany.ORCID 0000-0002-2933-7702
Anthony A HymanMax Planck Institute of Molecular Cell Biology and Genetics; Dresden, Saxony, 01307, Germany.ORCID 0000-0003-0851-704X
Donald HilvertLaboratory of Organic Chemistry, ETH Zurich, Zurich, Switzerland.ORCID 0000-0002-3941-621X
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-7896-6217

Funding

De Novo Design of Minibinder Antagonists for COVID-19 and Future PandemicsR01AI160052 · NIAID · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID, FULLER, DEBORAH H. · 2021 to 2025
$3.5M
Designed Vehicles for Blood Brain Barrier TraversalR01AG063845 · NIA · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2019 to 2023
$2.5M
NIAID NIH HHS R01 AI160052NIA NIH HHS R01 AG063845
6 · The paper itself

Abstract

Although significant progress has been made in creating

Identifiers

PMID41332769
PMCPMC12667880

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.