ArticleFrontiers in oncology2025
Impact of clinical and dosimetric factors on severe oral mucositis in head and neck cancer: insights from a phase II clinical trial.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Oral mucositis (OM) is the most common acute treatment-limiting adverse effect in patients with head and neck cancer (HNC), particularly following concomitant radiotherapy (RT) and systemic therapy. However, the effects of clinical and dosimetric parameters on the onset of severe OM remain controversial. We aimed to determine the association between clinical and dosimetric parameters and severe OM in the oral and pharyngeal mucosae in a randomized phase II clinical trial. Patients and methods: A subgroup analysis of data from a clinical trial was conducted to assess the efficacy of a 3% melatonin oral gel (Mucomel Results: The following variables were significantly associated with G3 OM in the oral mucosa: oropharyngeal localization ( Conclusion: Oropharyngeal cancer, cetuximab, and low and intermediate RT dose to the oral cavity mucosa were significantly associated with the onset of severe oral mucositis. Given the association between these previous factors with a higher risk of G3 OM, they should be considered during treatment planning and dosimetry in patients treated with cetuximab for oropharyngeal cancer.
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