ReviewiScience2025
Understanding microbiota-driven oncogenesis: The role of metabolites in tumorigenesis.
Review in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Microplastics and heavy metals dynamics: a potential threat to soil health and food safety.Plant cell reports · 2026Review
- Gut Microbiota: A Potential Role in Modulating Carcinogenesis and Response to Anti-Cancer Therapies.Cancer reports (Hoboken, N.J.) · 2026Review
- Interplay of Microbiome, Oxidative Stress and Inflammation in Health and Disease.Antioxidants (Basel, Switzerland) · 2026Review
- Decoding Microbiota in Genitourinary Oncology: Biological Mechanisms and Clinical Implications-A Narrative Review.Cancers · 2026Review
- Colorectal cancer in ulcerative colitis: unraveling mechanisms and advancing surveillance and chemoprevention.Frontiers in oncology · 2026Review
- From Symbiont to Potential Carcinogenic Contributor: Examining the Pathogenic Evolution ofInfection and drug resistance · 2026Review
- The diet-microbiota-inflammation axis and colorectal cancer.Frontiers in oncology · 2026Review
- The Central Role of m6A as Epigenetic Regulator in Metabolic Disorders of Therapeutic Potential and Clinical Implications.Molecular neurobiology · 2025Review
- The Gut-Prostate Axis: Decoding the Interplay of Environmental Factors, Microbial Metabolites, and Hormonal Regulation in Prostate Cancer Pathogenesis.Technology in cancer research & treatmentReview
Corrections and comments
- Retracted
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiota profoundly influence human health through its composition and metabolic activity, which are shaped by diet and host factors. Disruption of this equilibrium, known as dysbiosis, has been implicated in cancer development. Microbial metabolites act as key mediators connecting the gut microbiome to tumor progression by altering the tumor microenvironment and modulating signaling pathways in tumor and immune cells. This review examines the mechanistic links between the gut microbiota, its metabolites, and tumorigenesis, emphasizing how microbial metabolism of host- and diet-derived compounds affects oncogenic and genotoxic processes in colorectal cancer (CRC). It also explores how dietary and host factors modulate microbial composition and function, influencing cancer susceptibility. Understanding these interconnected processes provides conceptual insight into the microbiota-cancer axis and highlights opportunities for microbiome-targeted interventions in cancer prevention and therapy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.