ArticleResearch square2025
Altered Phenotype and Gene Expression of Regulatory T cells (Tregs) in Children with Autism, and the Relationship with Comorbid Gastrointestinal Symptoms.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
3 authors.
Funding
Abstract
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social deficits and stereotypic behaviors. Increased numbers of inflammatory cells and their mediators have been found in peripheral blood, brain, and gastrointestinal (GI) tissues of individuals with ASD. Regulatory T cells (Tregs) play a crucial role in suppressing inflammatory processes that, if disrupted, can result in inflammation and development of a variety of immunological conditions. In this study, we sought to characterize Tregs populations using flow cytometry and gene transcriptomic approaches in children with ASD (n = 36) and typically developing (TD) children (n = 18) enrolled in the Childhood Autism Risk from Genetics and Environment (CHARGE) study. We also examined differences in the frequencies of activated Tregs in ASD groups when stratified by co-occurring GI status. The frequency of gut homing α4b7
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.