ArticleResearch square2025
The Association of Hypertensive Disorders in Pregnancy with Offspring Kidney Function from Adolescence into Young Adulthood.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To estimate the association of hypertensive disorders in pregnancy (HDP) with offspring kidney function in adolescence and young adulthood in individuals born preterm with very low birth weight. Study Design: Secondary analysis of data from a prospective cohort study of individuals born preterm with very low or extremely low birth weight (< 1500 g). The 213 participants were assessed at 14-15 and 19-23 years of age. Outcomes were estimated glomerular filtration rate (eGFR) and first-morning albumin-to-creatinine ratio (ACR). We estimated the relationships with multivariable generalized linear models informed by directed acyclic graphs. Causal mediation analysis was also performed to evaluate if adolescent kidney function indirectly mediated the effect of maternal HTN on young adulthood kidney function. Results: 37% ( Conclusion: We found no significant association between HDP and offspring kidney function in adolescence and young adulthood, and no evidence of mediation through adolescent kidney function. Next steps in this research may look to investigate the relationship of severity of prematurity on offspring kidney function, as HDP are a factor in premature births and the degree of prematurity.
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