ReviewCureus2025
Effectiveness of Negative Pressure Wound Therapy and Advanced Interventions in Preventing Surgical Site Infections: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgical site infections (SSIs) are a major cause of postoperative morbidity and increased healthcare costs. Negative pressure wound therapy (NPWT) and other advanced wound dressings have been widely adopted to mitigate this risk; however, evidence of their effectiveness across diverse surgical settings remains inconsistent. This systematic review aims to evaluate the effectiveness of NPWT and advanced interventions in preventing SSIs compared to conventional dressings or standard care. A systematic search was conducted across five electronic databases and registers (PubMed, Excerpta Medica database (Embase), Scopus, Web of Science, ClinicalTrials.gov) for randomized controlled trials (RCTs) published up to 2025. Studies comparing NPWT or advanced dressings to conventional care for SSI prevention in any surgical population were included. Study selection, data extraction, and risk of bias assessment using the Cochrane Risk of Bias 2 (RoB 2) tool were performed by independent reviewers. A narrative synthesis was conducted due to clinical heterogeneity. Eight RCTs were included, encompassing procedures such as emergency laparotomy, vascular surgery, cesarean section, and orthopedic trauma. The results demonstrated that the effectiveness of advanced interventions is highly context-dependent. NPWT significantly reduced SSIs in open inguinal vascular surgery, and a dialkylcarbamoyl chloride (DACC)-impregnated dressing was effective following cesarean section. In contrast, the largest RCT found no benefit of incisional NPWT after emergency laparotomy. Evidence in orthopedic trauma was mixed. The majority of included trials were assessed as having a low risk of bias. The effectiveness of NPWT and advanced wound interventions in preventing SSIs is not universal but is contingent on the specific surgical context. These technologies should be applied selectively, targeting patient populations and procedures where a clear benefit has been demonstrated, rather than being used routinely. Future research should focus on identifying predictive factors to guide the cost-effective, personalized application of these therapies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.