ArticleFrontiers in bioengineering and biotechnology2025
Biodegradable and injectable curcumin-loaded hydrogel for the prevention of postoperative intrauterine adhesion.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Engineering Hydrogels for Intrauterine Adhesion Therapy and Endometrial Regeneration.Gels (Basel, Switzerland) · 2026Review
- Hardened ground: ECM stiffness as a unifying biomechanical driver of reproductive stem cell aging.Biogerontology · 2026Review
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Authors and funding
5 authors.
Funding
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Abstract
Intrauterine adhesions (IUAs) are essentially fibrosis of the endometrium within the uterine cavity. It is a common cause of infertility in women and seriously affects their physical and mental health. Current therapeutic strategies have failed to reach satisfactory outcomes. Injectable and self-healing uterine hydrogels with antifibrotic properties would be efficient in preventing IUA. In this work, we prepared curcumin-loaded carboxymethyl chitosan (CMC)-oxidized hyaluronic acid (OHA) intrauterine hydrogel (Cur@CMC-OHA hydrogel) with antifibrotic properties, and its injectable and self-healing properties could be adapted to the morphostructures of the uterine cavity. The hydrogels exhibited tissue adhesive power, which is ideal for stable uterine cavity retention and therapeutic outcomes.
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