ReviewVeterinary world2025
Experimental models of epilepsy: A comprehensive review of mechanisms, translational relevance, and future directions.
Review in Veterinary world, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Unraveling the role of FGF21 in epilepsy disease: mechanistic insights and therapeutic Potential.Metabolic brain disease · 2026Review
- Transcriptomic Challenges We Faced with Animal Models for Neurological Disorders.Current issues in molecular biology · 2026Review
- Insulin resistance and epilepsy: an emerging pathophysiological nexus.Metabolic brain disease · 2026Review
- Intranasal Biodegradable Nanomedicine for Epilepsy Management: Targeting the Brain Beyond the Blood-Brain Barrier.International journal of nanomedicine · 2026Review
- Sleep and circadian rhythm disruptions in animal models of temporal lobe epilepsy.Frontiers in neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is a chronic neurological disorder characterized by recurrent seizures, affecting millions worldwide. Experimental models play a crucial role in understanding the pathophysiology of seizures and in developing novel antiepileptic therapies. This review summarizes the major experimental models of epilepsy, including chemically induced, electrically induced, and genetic approaches. The strengths, limitations, and translational relevance of each model are discussed with particular emphasis on their applicability to human epilepsy subtypes, such as generalized tonic-clonic and temporal lobe epilepsy. Advances in neuroimaging, omics technologies, and artificial intelligence-based analytics are highlighted for their potential to enhance model accuracy and predictive validity. Ethical considerations, including the principles of replacement, reduction, and refinement, are also emphasized. By integrating classical models with emerging technologies, this review provides a comprehensive framework to guide future research aimed at improving therapeutic strategies and bridging the gap between pre-clinical and clinical epilepsy research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.