Evidence map›Paper›PMID 41334246›Full record

ArticleJAMIA open2025

Biomedical data repositories require governance for artificial intelligence/machine learning applications at every step.

Ellen Wright Clayton, Susannah Rose, Camille Nebecker, Laurie Novak, Yael Bensoussan, You Chen, Benjamin X Collins, Ashley Cordes, Barbara J Evans, Kadija S Ferryman and 11 more

Erratum issuedAbstract read
In one paragraph

Article in JAMIA open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Ellen Wright ClaytonCenter for Biomedical Ethics and Society, Vanderbilt University Medical Center, Nashville, TN 37203, United States.
Susannah RoseDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37203, United States.ORCID https://orcid.org/0000-0001-5895-7460
Camille NebeckerHerbert Wertheim School of Public Health & Human Longevity Science, University of California San Diego, San Diego, CA 92092, United States.
Laurie NovakDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37203, United States.
Yael BensoussanDepartment of Otolaryngology, Head & Neck Surgery, University of South Florida Morsani College of Medicine, Tampa, FL 33612, United States.
You ChenDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37203, United States.
Benjamin X CollinsDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37203, United States.
Ashley CordesIndigenous Media Studies in ENVS and Data Science, University of Oregon, Eugene, OR 97403, United States.
Barbara J EvansSchool of Law, University of Florida, Gainesville, FL 32611, United States.ORCID https://orcid.org/0000-0001-8115-7971
Kadija S FerrymanDepartment of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States.
Samantha HurstHerbert Wertheim School of Public Health & Human Longevity Science, University of California San Diego, San Diego, CA 92092, United States.
Xiaoqian JiangDepartment of Health Data Science and Artificial Intelligence, McWilliams School, University of Texas Health Science Center at Houston, Houston, TX 77030, United States.ORCID https://orcid.org/0000-0001-9933-2205
Aaron Y LeeDepartment of Ophthalmology, University of Washington, Seattle, WA 98195, United States.
Shannon McWeeneyCancer Data Science, Oregon Health Science University Knight Cancer Institute, Portland, OR 97239, United States.
Jillian ParkerDepartment of Medicine, University of California San Diego, San Diego, CA 92092, United States.
Jean-Christophe Bélisle-PiponFaculty of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Eric RosenthalDivision of Neurocritical Care, Harvard Medical School, Boston, MA 02114, United States.
Zhijun YinDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37203, United States.
Joseph YrachetaNative BioData Consortium, Eagle Butte, SD 57625, United States.
Bradley Adam MalinDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37203, United States.
Bridge2AI Ethics Working Group

Funding

Bridge2AI:Salutogenesis Data Generation ProjectOT2OD032644 · OD · WASHINGTON UNIVERSITY · PI BAXTER, SALLY LIU, CHUTE, CHRISTOPHER G · 2022 to 2025
$32.7M
Bridge2AI: Patient-Focused Collaborative Hospital Repository Uniting Standards (CHoRUS) for Equitable AIOT2OD032701 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BIHORAC, AZRA, CLERMONT, GILLES · 2022 to 2025
$24.6M
Bridge2AI: Cell Maps for AI (CM4AI) Data Generation ProjectOT2OD032742 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jean-Christophe Bélisle-Pipon, TIMOTHY W CLARK · 2022 to 2026
$21.5M
Bridge2AI: Voice as a Biomarker of Health - Building an ethically sourced, bioaccoustic database to understand disease like never beforeOT2OD032720 · OD · UNIVERSITY OF SOUTH FLORIDA · PI BENSOUSSAN, YAEL EMILIE, BÉLISLE-PIPON, JEAN-CHRISTOPHE · 2022 to 2025
$18.0M
Ethics Core (FABRIC)U54HG012510 · NHGRI · YALE UNIVERSITY · PI MALIN, BRADLEY A. · 2022 to 2025
$11.2M
NHGRI NIH HHS U54 HG012510NIH HHS OT2 OD032644NIH HHS OT2 OD032701NIH HHS OT2 OD032720NIH HHS OT2 OD032742
6 · The paper itself

Abstract

Objectives: The NIH's Bridge2AI Program has funded 4 "new flagship biomedical and behavioral datasets that are properly documented and ready for use with AI [artificial intelligence] or ML [machine learning] technologies" to promote the adoption of AI. This article discusses the challenges and lessons learned in data collection and governance to ensure their responsible use. Materials and Methods: We outline major steps involved in creating and using these datasets in ethically acceptable ways, including (1) data selection-what data are being selected and why, (2) increasing attention to public concerns, (3) the role of participant consent depending on data source, (4) ensuring responsible use, (5) where and how data are stored, (6) what control participants have over data sharing, (7) data access, and (8) data download. Results: We discuss ethical, legal, social, and practical challenges raised at each step of creating AI-ready datasets, noting the importance of addressing issues of future data storage and use. We identify some of the many choices that these projects have made, including how to incorporate public input, where to store data, and defining criteria for access to and downloading data. Discussion: The processes involved in the establishment and governance of the Bridge2AI datasets vary widely but have common elements, suggesting opportunities for future programs to lean upon Bridge2AI strategies. Conclusions: This article discusses the challenges and lessons learned in data collection and governance to ensure their responsible use, particularly as confronted by the 4 distinct projects funded by this program.

Indexed as

data accessdata privacygovernanceinformed consent

Identifiers

PMID41334246
PMCPMC12668681

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.