ReviewFrontiers in nutrition2025
Transforming coffee from an empirical beverage to a targeted nutritional intervention: health effects of coffee's core functional components on chronic diseases.
Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Characterization of Spent Coffee Grounds' Polyphenol Fraction and Its Potential as a Low-Cost Tool for Bioactivity-Guided Nephroprotective Modulation of Gut-Kidney Axis and NF-κB/Nrf2/TGF-β Signaling in Hypertension-Associated Kidney Injury.Antioxidants (Basel, Switzerland) · 2026Article
- Panamanian Geisha Coffee Exhibits Antioxidant and Vasorelaxant Activities with a Favorable Safety Profile.Foods (Basel, Switzerland) · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As one of the most widely consumed beverages worldwide, coffee has garnered increasing scientific interest due to its potential health benefit in recent decades. Epidemiological studies have consistently shown that regular coffee consumption significantly reduces the incidence risks of various chronic diseases, including type 2 diabetes mellitus (T2DM), Alzheimer's disease (AD), cardiovascular disorders, and nephropathies. Pharmacological research further supports these findings, linking the protective effects of coffee to its complex composition of bioactive compounds. Coffee beans contain over 1,000 such compounds, with caffeine, trigonelline, chlorogenic acids (CGAs), cafestol, kahweol, and melanoidins constituting the core functional components. These phytochemicals act through multi-target, synergistic mechanisms that regulate neurological functions, metabolic homeostasis, and inflammatory pathways. This review systematically explores the major bioactive constituents of coffee, focusing on the molecular mechanisms underlying four key biological activities associated with chronic disease prevention: neuroprotection, anti-diabetic/anti-obesity effects, antioxidant activity, and anti-inflammatory properties. By elucidating these pharmacological pathways, we aim to establish a molecular theoretical foundation for repositioning coffee from an empirical beverage into a targeted nutritional intervention agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.