ArticleResearch and practice in thrombosis and haemostasis2025
Characteristics and outcomes of thromboembolism following cardiac transplant: a multi-institutional retrospective study.
Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Thromboembolism (TE) is a serious and potentially life-threatening complication following orthotopic heart transplant (OHT) that is not well described in current literature. Objectives: We aimed to characterize postoperative venous (VTE) and arterial thromboembolism (ATE) after OHT and describe their impact on survival. Methods: We identified adult (aged ≥18 years) patients undergoing OHT from 2016 to 2022 in the TriNetX Research Network, which includes data from >140 million individuals from 102 institutions. Our primary outcomes were VTE or ATE within 30 days posttransplant and 1-year mortality. We used multivariable logistic regression to evaluate risk factors associated with TE and the association between TE and 1-year mortality. Results: Among 2625 patients from 28 institutions who underwent OHT, the 30-day incidence of TE was 34% (VTE 27%, ATE 16%), and 1-year mortality was 6%. Patients experiencing TE were older (54 vs 52 years, Conclusion: TE is common after OHT and may reflect underlying patient comorbidity, emphasizing the need for high clinical suspicion of TE post OHT to mitigate morbidity and mortality.
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