ReviewJournal of tissue engineering
Microfluidic organ-on-a-chip for modeling coronary artery disease: Recent applications, limitations and potential.
Review in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A Four-Channel Microfluidic Vascular-Wall Chip for Modeling Early Atherosclerosis-Related Endothelial Dysfunction and Evaluating Combined Anti-Inflammatory Treatment.Micromachines · 2026Article
- Multifunctional Biomaterial Strategies to Regulate Inflammation and Promote Kidney Repair.Biomaterials research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary artery disease (CAD) encompasses a spectrum of pathologies driven by atherosclerosis, trauma, inflammation, or other etiologies that compromise coronary morphology and function, ultimately leading to myocardial ischemia and infarction. While organ-on-a-chip (OOC) technology has emerged as a transformative tool for cardiovascular research, existing reviews have consistently marginalized coronary-specific pathophysiology, treating it merely as a subset of generic vascular biology. This review presents the first dedicated, critical analysis of microphysiological system (MPS) engineered explicitly as CAD-on-a-chip platform. We deliberately depart from generalized vascular models by exclusively evaluating systems designed to recapitulate the unique coronary-specific hallmarks: distinct geometric constraints, pro-inflammatory microenvironments, and dynamic hemodynamic shear stress profiles inherent to human coronary arteries. Following a concise introduction to OOC fabrication materials and techniques, we systematically present vessel-on-a-chip (VOC) models derived from diverse cellular sources. We then emphasize the biomedical applications of VOC in CAD field and analyze key CAD-specific pathological processes, including flow-mediated endothelial dysfunction, atherosclerotic plaque formation, plaque rupture-induced atherothrombosis, and coronary artery aneurysm. Finally, we critically discuss current limitations and outline future directions of OOC technology in CAD research. This review by focusing on the specific pathological features of CAD and the requirements for in vitro modeling, aim to establish a targeted knowledge framework to promote the clinical transformation of VOC technology in CAD diagnosis and treatment.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.