SynthesisFrontiers in endocrinology2025
Inflammation-mediated effects of diabetes mellitus on male fertility: a systematic review and meta-analysis.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Metabolic Syndrome and Male Infertility: The Role of Obesity and Chronic Inflammation.Biomedicines · 2026Review
- The link between diabetes and male infertility: mechanisms and implications.Scientific reports · 2026Article
- ANGPTL4-dependent metabolic reprogramming fuels RhoA signalling and microvascular dysfunction in diabetes.Acta diabetologica · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diabetes mellitus (DM) has emerged as a rapidly growing global health problem, imposing substantial socioeconomic burdens and multidimensional health consequences, including adverse effects on male fertility. Although accumulating evidence suggests associations between DM and male reproductive dysfunction, comprehensive mechanistic insights, particularly through inflammatory pathways, remain inadequately elucidated. Method: We conducted a systematic literature search on Web of Science, Embase, and PubMed databases (1972-2022) to investigate DM-related male infertility through meta-analysis. Following PRISMA guidelines, eight of 168 studies on type 1 diabetes (T1D) and nine of 185 studies on type 2 diabetes (T2D) were included to screen the relationship between diabetes and male infertility. In addition, 10 of 840 inflammation-related studies (1961-2022) underwent rigorous selection for mechanistic exploration. Meta-analysis was conducted to evaluate the summary relative risk (RR) and 95% confidence intervals (CIs) across the combined studies. Results: Meta-analysis demonstrated a significant impairment of male fertility in diabetic populations. Subgroup analyses revealed that T2D is more likely to cause male infertility compared to T1D. Despite low between-study heterogeneity, inflammation biomarkers (e.g., TNF-α) were implicated in diabetes-induced male infertility. Transcriptomic analyses further identified enriched inflammatory pathways and altered expression of fertility-related genes. Conclusion: Current evidence indicates that diabetes adversely affects male fertility through inflammatory pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.