Evidence map›Paper›PMID 41334452›Full record

ArticleCurrent research in pharmacology and drug discovery2025

MAO-B inhibition by selegiline blunts cardiac functions improved by high-fat diet: Role of inflammation, apoptosis, and calcium-handling.

Szabolcs Hambalkó, Csilla Pelyhe, Csenger Kovácsházi, Bence Kenyeres, Bernadett Kiss, Bence Ágg, Tamás G Gergely, Bennet Y Weber, András Makkos, Gábor B Brenner and 19 more

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Article in Current research in pharmacology and drug discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Szabolcs HambalkóSemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.
Csilla PelyheSemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.
Csenger KovácsháziSemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.
Bence KenyeresSemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.
Bernadett KissSemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.
Bence ÁggSemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.
Tamás G GergelySemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.
Bennet Y WeberSemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.
András MakkosSemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.
Gábor B BrennerSemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.
Tímea KomlódiDepartment of Biochemistry, Semmelweis University, 37-47 Tuzolto Street, Budapest, 1094, Hungary.
László TretterDepartment of Biochemistry, Semmelweis University, 37-47 Tuzolto Street, Budapest, 1094, Hungary.
Csaba HorváthDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32, Bratislava, Slovak Republic.
Izabela JarabicováDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32, Bratislava, Slovak Republic.
Adriana AdameováDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32, Bratislava, Slovak Republic.
Anikó GörbeSemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.
Paola PoggiRemembrane S.r.L., Imola, Italy.
Alexandros ChatgilialogluRemembrane S.r.L., Imola, Italy.
Ildikó HorváthDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Domokos MáthéDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Krisztián SzigetiDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Attila OláhHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Tamás RadovitsHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Zoltán V VargaSemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.
Béla MerkelyHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Gary F BaxterSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, UK.
Rainer SchulzInstitute of Physiology, Justus-Liebig University Giessen, Giessen, Germany.
Péter FerdinandySemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.
Zoltán GiriczSemmelweis University, Department of Pharmacology and Pharmacotherapy, 1085, Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Obesity is a major risk factor for the development of cardiovascular disease. However, recent research shows that moderate obesity reduces the risk of developing cardiovascular disease. We evidenced before that MAO-B inhibitor selegiline reduced visceral adiposity. Aim: Therefore, our aim was to investigate cardiac effects of selegiline in moderate obesity in rats treated with a high-fat diet (HFD). Key findings: We demonstrated that HFD improved cardiac contractility parameters, which were reversed by selegiline. Enhanced contractility might be attributed to an increased sarcoplasmic/endoplasmic reticulum Ca Conclusion: In conclusion, moderate obesity improves cardiac function through Ca

Indexed as

Calcium homeostasisHeartObesityObesity paradoxSelegilineSERCA2a

Identifiers

PMID41334452
PMCPMC12666686

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.