ArticleJHEP reports : innovation in hepatology2025
Diagnostic accuracy of transient elastography in MASLD is independent of MRI-PDFF steatosis in a multicenter study.
Article in JHEP reports : innovation in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03245606 (Combining MRI Steatosis Assessment and Transient Elastography to Improve Liver Fibrosis Diagnosis in Non-Alcoholic Fatty Liver Disease), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combining MRI Steatosis Assessment and Transient Elastography to Improve Liver Fibrosis Diagnosis in Non-Alcoholic Fatty Liver Disease (NAFLD)
Who cites it
1 citing paper in PubMed.
- Advances in quantitative ultrasound for metabolic dysfunction-associated steatotic liver disease diagnosis.Frontiers in physiology · 2026Review
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Transient elastography (TE) can be used to accurately screen for severe liver fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD). However, some studies suggest that steatosis influences liver stiffness measurement (LSM). Thus, treatment that modifies steatosis might impact the relevance of TE in the management of patients. The use of magnetic resonance imaging (MRI)-proton density fat fraction (PDFF) has shown good reliability and accuracy for quantifying hepatic steatosis. Therefore, the aim of our study was to evaluate the performance of TE combined with MRI-PDFF for the diagnosis of severe fibrosis in patients with MASLD. The study is registered at ClinicalTrials.gov (NCT03245606). Methods: In this prospective multicenter study, patients with MASLD and indication for biopsy underwent MRI and TE within the same month. Biopsies were centrally reviewed using the steatosis, activity, and fibrosis (SAF) score. PDFF was centrally quantified using MRQuantif software. AUROCs for the diagnosis of fibrosis ≥F2 and ≥F3 were determined for LSM alone and LSM combined with PDFF as a continuous or categorical variable in a logistic regression. Results: In total, 208 patients were studied. The median age was 59 years, 63.9% were men, the median body mass index (BMI) was 31.2 kg/m Conclusions: TE performance for the diagnosis of liver fibrosis does not appear to be affected by the level of liver steatosis. Thus, quantifying hepatic steatosis using MRI-PDFF allows a comprehensive and accurate assessment of liver steatosis. Impact and implications: TE is a reliable tool for screening severe liver fibrosis in patients with MASLD. However, some studies suggest that the severity of steatosis influences LSM. Thus, treatment that modifies steatosis might impact the relevance of TE in the management of patients. This prospective multicenter study evaluated whether combining TE with MRI-PDFF, a precise method for measuring liver fat, could improve diagnostic accuracy for severe fibrosis in patients with MASLD. Our results show that TE performance in fibrosis diagnosis remains consistent regardless of steatosis levels, reinforcing the use of non-invasive methods, particularly TE, for regular patient monitoring, even as steatosis levels fluctuate.
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