Observational studyJournal of the American Heart Association2025
Prevalence and Factors Associated With Atrial Fibrillation Among Young Patients With Ischemic Stroke.
Observational study in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Predictive accuracy of left atrial strain parameters for risk of atrial fibrillation recurrence: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtrial fibrillation (AF) is an important risk factor for stroke with increasing prevalence and incidence, especially in older people. However, prevalence and risk factors of AF in young patients with stroke remain unclear. The aim of this study was to determine the prevalence and factors associated with AF in young patients with stroke.
methodsWe included patients with first-ever ischemic stroke (18-49 years) with imaging-confirmed ischemia from the ODYSSEY (Observational Dutch Young Symptomatic Stroke) study. All patients underwent cardiac evaluation, including ECG, cardiac rhythm monitoring, and echocardiography.
resultsOf 1259 patients (mean age 41.8 years, SD 7.5, 47.3% female), 13 patients (1%) had a known history of AF. Additionally, AF was found in 19 patients (1.5%), predominantly detected during telemetric observation within first 24 hours. Patients with AF had higher National Institutes of Health Stroke Scale scores at admission (adjusted odds ratio [aOR], 1.1 [95% CI, 1.0-1.2]) and more frequent history of cardiac pathology (aOR, 5.0 [95% CI, 2.2-10.9]). The most important factors associated with AF were history of heart valve abnormalities (OR, 6.5 [95% CI, 2.1-16.7]) and hypertension (aOR, 2.5 [95% CI, 1.1-6.1]). Recurrence of ischemic stroke occurred more frequently in patients with AF (aOR, 2.5 [95% CI, 1.0-5.9], adjusted hazard ratio, 2.2 [95% CI, 1.0-4.7]) compared with those without AF.
conclusionsApproximately 2.5% of young patients with stroke have AF, with about half previously known and half detected through rhythm observation, all within 24 hours. Furthermore, most patients with AF had structural cardiac pathology, especially heart valve abnormalities, suggesting an increased risk of developing AF. Patients with AF had more severe strokes and higher recurrence of vascular events.
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