Evidence mapPaperPMID 41334749Full record

Trial reportJournal of the American Heart Association2025

Enhancing Comorbidity Management in Patients With Hemorrhagic Stroke via an Electronic Health Record-Linked Best Practice Alert: A Pre/Post Study.

Savvina Prapiadou, Reinier W P Tack, Tamara N Kimball, Samantha Mora, Devanshi Choksi, Marie-Gabrielle Duperron, Jasper R Senff, Christina Kourkoulis, Sanjula D Singh, Nirupama Yechoor and 5 more

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05643001 (Precision Clinical and Genetic Tools for Brain Health in Hemorrhagic Stroke), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05643001 nacompletednot on this map

Precision Clinical and Genetic Tools for Brain Health in Hemorrhagic Stroke

TypeinterventionalSponsorMassachusetts General HospitalRan2023 to 2025Enrolled340ConditionsHemorrhagic StrokeArmsIn-patient and out-patient electronic health record alert
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Savvina PrapiadouDepartment of Neurology Brigham and Women's Hospital Boston MA USA.ORCID 0000-0001-7415-2566
Reinier W P TackBroad Institute of MIT and Harvard Cambridge MA USA.ORCID 0000-0003-3204-0309
Tamara N KimballDepartment of Neurology Brigham and Women's Hospital Boston MA USA.ORCID 0000-0002-1107-0771
Samantha MoraBroad Institute of MIT and Harvard Cambridge MA USA.
Devanshi ChoksiHenry and Allison McCance Center for Brain Health Massachusetts General Hospital Boston MA USA.ORCID 0009-0009-6312-5621
Marie-Gabrielle DuperronDepartment of Neurology Brigham and Women's Hospital Boston MA USA.ORCID 0000-0001-7408-7792
Jasper R SenffHenry and Allison McCance Center for Brain Health Massachusetts General Hospital Boston MA USA.
Christina KourkoulisBroad Institute of MIT and Harvard Cambridge MA USA.ORCID 0000-0001-6330-9169
Sanjula D SinghHenry and Allison McCance Center for Brain Health Massachusetts General Hospital Boston MA USA.ORCID 0000-0001-9304-8107
Nirupama YechoorHenry and Allison McCance Center for Brain Health Massachusetts General Hospital Boston MA USA.ORCID 0000-0001-6479-9155
Livia ParodiDepartment of Neurology Brigham and Women's Hospital Boston MA USA.ORCID 0000-0003-0605-2381
Benjamin Y Q TanBroad Institute of MIT and Harvard Cambridge MA USA.ORCID 0000-0003-1824-9077
Jonathan RosandBroad Institute of MIT and Harvard Cambridge MA USA.ORCID 0000-0002-1014-9138
Ernst MayerhoferBroad Institute of MIT and Harvard Cambridge MA USA.ORCID 0000-0001-8902-4209
Christopher D AndersonDepartment of Neurology Brigham and Women's Hospital Boston MA USA.ORCID 0000-0002-0053-2002

Funding

American Heart Association-American Stroke Association 812095
6 · The paper itself

Abstract

backgroundSurvivors of hemorrhagic stroke exhibit a high burden of cerebrovascular risk factors, including hyperlipidemia and diabetes, which can impact future risk of recurrence and major adverse cardiovascular events. Systematic evaluation and management of these comorbidities during hospitalization remains suboptimal, despite the availability of effective treatment strategies. This study aimed to determine whether an electronic health record-based intervention improves assessment and management of hyperlipidemia and diabetes after hemorrhagic stroke.

methodsWe conducted a prospective cohort study comparing a historical cohort of 314 consecutive patients with primary intracerebral hemorrhage (2016-2019) with a prospective intervention cohort of 296 patients with hemorrhagic stroke (2023-2024) at a single tertiary care center. The intervention was composed of an electronic health record-deployed best practice alert to prompt providers to order low-density lipoprotein cholesterol (LDL-C) and glycated hemoglobin (HbA

resultsFollowing the intervention, the cumulative incidence of HbA

conclusionsOur electronic health record-based intervention significantly improved the proportion of patients with hemorrhagic stroke evaluated for key comorbidities during acute hospitalization. However, future studies are needed to assess whether increased evaluations improve long-term management and outcomes. REGISTRATION: URL: Clinicaltrials.gov; Unique Identifier: NCT05643001.

Indexed as

Diabetes MellitusElectronic Health RecordsHemorrhagic StrokeHyperlipidemiasAgedCholesterol, LDLComorbidityFemaleGlycated HemoglobinHumansMaleMiddle AgedProspective StudiesRisk FactorsCholesterol, LDLGlycated Hemoglobinhemoglobin A1c protein, humanbest practice alertcomorbidity managementdiabeteshemorrhagic strokehyperlipidemia

Identifiers

PMID41334749
PMCPMC12826920

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.