ArticleJournal of the American Heart Association2025
Association of Epicardial Adipose Tissue With Bradyarrhythmias: A Matched Case-Control Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association Between Bradyarrhythmia Requiring Permanent Pacemaker Implantation and Epicardial Adipose Tissue in Elderly Patients.Journal of arrhythmia · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpicardial adipose tissue (EAT) is implicated in exerting potential proarrhythmic effects. The relationship between EAT and tachyarrhythmias is well documented. However, the connection between EAT and bradyarrhythmias has not been comprehensively explored. This study aimed to investigate the association between EAT and bradyarrhythmias.
methodsWe retrospectively quantified the volume and density of EAT using chest computed tomography scans from patients with bradyarrhythmias and case-matched controls. Measurements were obtained through manual pericardial contour tracing with a standardized Hounsfield unit threshold of -200 to -50 Hounsfield units.
resultsA total of 652 patients were included, comprising 326 patients with bradyarrhythmias (age 74.00 [interquartile range, 64.00-81.00] years, 46.01% female) and 326 matched controls (age 72.50 [interquartile range, 63.00-80.00] years, 46.01% female). Compared with the matched control group, the bradyarrhythmia group had a significantly greater volume (119.13 [interquartile range, 87.30-151.68] cm
conclusionsPatients with bradyarrhythmia demonstrated significantly higher EAT volumes compared with matched controls, with a progressive increase observed across advancing grades of AVB. This dose-dependent relationship between EAT burden and conduction system impairment underscores its potential role as a modifiable influencing factor in arrhythmogenesis. Further investigations are warranted to determine whether targeted EAT reduction could mitigate conduction abnormalities. REGISTRATION: URL: https://www.chictr.org.cn; Unique Identifier: ChiCTR2400088446.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.