Trial reportAnnals of surgical oncology2026
Preoperative Short-Term Nutrition and Exercise Trial Program for Patients with Esophageal Cancer: A Randomized Clinical Trial: Thoracic Oncology.
Trial report in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Pancreatic ductal adenocarcinoma and pancreatic surgery in the 21st century: triumphs, turning points, and unresolved challenges.Updates in surgery · 2026Review
- ASO Author Reflections: The Liver Left Behind-Background Fibrosis as a Determinant of Intrahepatic Recurrence After Resection of Colorectal Liver Metastases.Annals of surgical oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEsophagectomy confers high postoperative morbidity and mortality. To improve postoperative outcomes, this study investigated the effectiveness of a 2-week prehabilitation program on the preoperative cardiopulmonary function of patients undergoing surgery for esophageal cancer.
methodsIn this parallel-group, open-label, superiority randomized clinical trial, participants were randomly assigned (1:1) to the multimodal prehabilitation (m-prehab) group or the control group and received exercise instruction from a physical therapist. The m-prehab group received additional exercise instruction 1 week later and were administered additional oral nutritional supplements (430 kcal and 47 g protein 2 weeks before surgery). The primary outcome was change in the anaerobic threshold (AT) from baseline to immediately before surgery.
resultsAmong the participants (42 men and 8 women; m-prehab [n = 25], control [n = 24]; mean age, 65.3 years), those in the m-prehab group consumed significantly more protein than those in the control group (76.8 ± 16.6 vs 61.6 ± 18.0 g/day, p < 0.01). The m-prehab and control groups showed no significant intergroup difference in preoperative daily step counts (7590 and 7910, respectively) or change in AT. Quadriceps strength increased significantly more in the m-prehab group than in the control group (3.7 ± 13.5 vs - 5.3 ± 16.0; p = 0.04), and the skeletal muscle index showed a nonsignificant but increasing trend (4.0 ± 6.5 vs 1.1 ± 4.8; p = 0.09). Estimated protein intake was unassociated, whereas preoperative step count was significantly correlated positively with change in AT (r = 0.412; p = 0.02).
conclusionsThis prehabilitation program increased preoperative protein intake but did not contribute to an increase in physical activity, nor did it result in significant differences in preoperative changes in AT. Trial Registration Japan Registry of Clinical Trials, Number: jRCTs041190075 ( https://jrct.niph.go.jp/en-latest-detail/jRCTs041190075 ).
Indexed as
Identifiers
41335173What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.