Evidence map›Paper›PMID 41335201›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Anemia, as an adverse event during chemoradiotherapy for head and neck cancer, contributes to a reduction in swallowing muscle mass and leads to dysphagia.

Nao Hashida, Kiyohito Hosokawa, Motoyuki Suzuki, Eri Okajima, Takanari Kawabe, Kenji Aruga, Itsuki Kitayama, Hiroshi Kato, Hirotaka Eguchi, Tosihiko Kishikawa and 5 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nao HashidaSwallowing Center, The University of Osaka Hospital, 2-15, Yamadaoka, Osaka, Suita City, 565-0871, Japan. nhashida@ent.med.osaka-u.ac.jp.
Kiyohito HosokawaSwallowing Center, The University of Osaka Hospital, 2-15, Yamadaoka, Osaka, Suita City, 565-0871, Japan.
Motoyuki SuzukiSwallowing Center, The University of Osaka Hospital, 2-15, Yamadaoka, Osaka, Suita City, 565-0871, Japan.
Eri OkajimaSwallowing Center, The University of Osaka Hospital, 2-15, Yamadaoka, Osaka, Suita City, 565-0871, Japan.
Takanari KawabeSwallowing Center, The University of Osaka Hospital, 2-15, Yamadaoka, Osaka, Suita City, 565-0871, Japan.
Kenji ArugaSwallowing Center, The University of Osaka Hospital, 2-15, Yamadaoka, Osaka, Suita City, 565-0871, Japan.
Itsuki KitayamaSwallowing Center, The University of Osaka Hospital, 2-15, Yamadaoka, Osaka, Suita City, 565-0871, Japan.
Hiroshi KatoDepartment of Otorhinolaryngology-Head and Neck Surgery, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, 565-0871, Japan.
Hirotaka EguchiDepartment of Otorhinolaryngology-Head and Neck Surgery, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, 565-0871, Japan.
Tosihiko KishikawaDepartment of Otorhinolaryngology-Head and Neck Surgery, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, 565-0871, Japan.
Hidenori TanakaDepartment of Otorhinolaryngology-Head and Neck Surgery, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, 565-0871, Japan.
Takeshi TsudaDepartment of Otorhinolaryngology-Head and Neck Surgery, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, 565-0871, Japan.
Takashi SatoDepartment of Otorhinolaryngology-Head and Neck Surgery, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, 565-0871, Japan.
Yukinori TakenakaDepartment of Otorhinolaryngology-Head and Neck Surgery, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, 565-0871, Japan.
Hidenori InoharaSwallowing Center, The University of Osaka Hospital, 2-15, Yamadaoka, Osaka, Suita City, 565-0871, Japan.

Funding

Japan Society for the Promotion of Science JP24H02727
6 · The paper itself

Abstract

backgroundChemoradiotherapy (CRT) for head and neck cancer (HNC) often leads to dysphagia and myelosuppression (e.g., neutropenia and anemia). This study investigated the associations between myelosuppression, muscle mass changes, and dysphagia in patients undergoing CRT for HNC.

methodsThis retrospective observational study included 136 patients with HNC who underwent curative CRT between January 2019 and August 2024. Anemia (hemoglobin ≤ 8.0 g/dL) and neutropenia (absolute neutrophil count < 1000/mm

resultsOn multivariate analysis, anemia was significantly associated with a decline in the TCM cross-sectional area (coefficient: 8.21, P < 0.001) and feeding tube dependency (odds ratio: 5.25, P = 0.02). In contrast, neutropenia had no significant impact on either.

conclusionsAnemia, an adverse effect of CRT for HNC, was an independent risk factor for feeding tube dependency at 3 months post-CRT and was significantly associated with a decline in the TCM cross-sectional area.

Indexed as

AnemiaChemoradiotherapyDeglutition DisordersHead and Neck NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedNeutropeniaRetrospective StudiesRisk FactorsAcute side effectsAnemiaChemoradiotherapySarcopeniaSarcopenic dysphagia

Identifiers

PMID41335201

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.